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    Pex11b peroxisomal biogenesis factor 11 beta [ Mus musculus (house mouse) ]

    Gene ID: 18632, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pex11bprovided by MGI
    Official Full Name
    peroxisomal biogenesis factor 11 betaprovided by MGI
    Primary source
    MGI:MGI:1338882
    See related
    Ensembl:ENSMUSG00000028102 AllianceGenome:MGI:1338882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PEX11beta; Pex11pbeta
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in peroxisome fission; regulation of peroxisome size; and signal transduction. Located in mitochondrion. Used to study Zellweger syndrome. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 14B. Orthologous to human PEX11B (peroxisomal biogenesis factor 11 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 21.3), kidney adult (RPKM 12.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pex11b in Genome Data Viewer
    Location:
    3 F2.1; 3 41.93 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96542673..96552697)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96635357..96645381)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330549D23 gene Neighboring gene Lix1-like Neighboring gene STARR-positive B cell enhancer ABC_E7929 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96439383-96439492 Neighboring gene RNA binding motif protein 8a Neighboring gene integrin, alpha 10 Neighboring gene ribosomal protein L21, pseudogene 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Potential readthrough

    Included gene: Itga10

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in peroxisome fission  
    involved_in peroxisome fission  
    involved_in peroxisome fission  
    involved_in peroxisome organization  
    involved_in peroxisome organization  
    involved_in regulation of peroxisome size  
    involved_in regulation of peroxisome size  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle  
    located_in mitochondrion PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in peroxisomal membrane  
    located_in peroxisomal membrane  
    located_in peroxisomal membrane  
    located_in peroxisome  
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    peroxisomal membrane protein 11B
    Names
    PEX11-beta
    peroxin-11B
    peroxisomal biogenesis factor 11b
    protein PEX11 homolog beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162387.1NP_001155859.1  peroxisomal membrane protein 11B isoform 1

      See identical proteins and their annotated locations for NP_001155859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK082279, AK082778, BB010355, BY789006, CD806660
      Consensus CDS
      CCDS17643.1
      UniProtKB/Swiss-Prot
      Q8C4G1, Q9D090, Q9Z210
      Related
      ENSMUSP00000037962.9, ENSMUST00000048766.15
      Conserved Domains (1) summary
      pfam05648
      Location:1250
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    2. NM_001162388.1NP_001155860.1  peroxisomal membrane protein 11B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC122037
      Consensus CDS
      CCDS51006.1
      UniProtKB/TrEMBL
      E9PXK7
      Related
      ENSMUSP00000126631.2, ENSMUST00000165842.3
      Conserved Domains (1) summary
      pfam05648
      Location:4236
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    3. NM_011069.3NP_035199.3  peroxisomal membrane protein 11B isoform 1

      See identical proteins and their annotated locations for NP_035199.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK011709, AK082778, BB010355, BY789006
      Consensus CDS
      CCDS17643.1
      UniProtKB/Swiss-Prot
      Q8C4G1, Q9D090, Q9Z210
      Related
      ENSMUSP00000113365.2, ENSMUST00000118557.8
      Conserved Domains (1) summary
      pfam05648
      Location:1250
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)

    RNA

    1. NR_027844.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK005236, AK082778, BB010355, BY789006
    2. NR_027845.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because it lacks a portion of the 5' coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA462527, AK082778, BB010355, BQ443231, BY285331, CB525686
      Related
      ENSMUST00000144962.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96542673..96552697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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