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    Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 26432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plod2provided by MGI
    Official Full Name
    procollagen lysine, 2-oxoglutarate 5-dioxygenase 2provided by MGI
    Primary source
    MGI:MGI:1347007
    See related
    Ensembl:ENSMUSG00000032374 AllianceGenome:MGI:1347007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LH2; Plod-2; D530025C14Rik
    Summary
    Predicted to enable procollagen-lysine 5-dioxygenase activity. Predicted to be involved in collagen fibril organization; hydroxylysine biosynthetic process; and peptidyl-lysine hydroxylation. Predicted to be located in rough endoplasmic reticulum membrane. Predicted to be active in several cellular components, including Golgi apparatus; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; brain; branchial arch; sensory organ; and skeleton. Orthologous to human PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 27.1), adrenal adult (RPKM 20.7) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plod2 in Genome Data Viewer
    Location:
    9 E3.3; 9 48.4 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (92421828..92490481)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (92539636..92608428)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene phospholipid scramblase 4 Neighboring gene STARR-seq mESC enhancer starr_24899 Neighboring gene RIKEN cDNA B430319G15 gene Neighboring gene predicted gene, 25417 Neighboring gene STARR-seq mESC enhancer starr_24900 Neighboring gene STARR-seq mESC enhancer starr_24901 Neighboring gene predicted gene 2495 Neighboring gene STARR-seq mESC enhancer starr_24902 Neighboring gene predicted gene 29396

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties. Bahraoui S, et al. Stem Cell Res Ther, 2024 Mar 7. PMID 38454524, Free PMC Article
    2. Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells. Pornprasertsuk S, et al. J Bone Miner Res, 2004 Aug. PMID 15231023
    3. Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization. Pornprasertsuk S, et al. J Bone Miner Res, 2005 Jan. PMID 15619673
    4. Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration. Nozaki R, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34875533, Free PMC Article
    5. Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression. Remst DF, et al. Osteoarthritis Cartilage, 2013 Jan. PMID 23069856

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the long form of Plod2 phenocopies contractures of Bruck syndrome-osteogenesis imperfecta.
      Title: Loss of the long form of Plod2 phenocopies contractures of Bruck syndrome-osteogenesis imperfecta.
    2. Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis.
      Title: Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis.
    3. The HIF-1alpha/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair.
      Title: The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair.
    4. PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties.
      Title: PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties.
    5. Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration.
      Title: Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration.
    6. Homozygous lysyl hydroxylase 2 knockout (LH2(-/-)) embryos failed to develop normally and died at early embryonic stage E10.5 with abnormal common ventricle in a heart, i.e., an insufficient wall, a thin ventricular wall, and loosely packed cells.
      Title: Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality.
    7. Data suggest a pro-metastatic GATA3 Transcription Factor (GATA3)- lysyl hydroxylases (LHs) axis for lung cancer, supporting the notion that targeting LHs may be useful for treating lung cancer.
      Title: Lysyl hydroxylases are transcription targets for GATA3 driving lung cancer cell metastasis.
    8. FKBP65 regulates LH2-mediated collagen cross-linking.
      Title: FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.
    9. The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology.
      Title: Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.
    10. Authors propose that lysyl hydroxylase 2, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental osteoarthritis.
      Title: Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-lysine 5-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-lysine 5-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-lysine 5-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hydroxylysine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine hydroxylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rough endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
    Names
    lysyl hydroxylase 2
    NP_001136388.1
    NP_036091.2
    XP_030100253.1
    XP_036010914.1
    XP_036010915.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142916.1 → NP_001136388.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as LH2b).
      Source sequence(s)
      AC165156, AF080572, AK033363, AV488215, BB644981, CF615856
      Consensus CDS
      CCDS52887.1
      UniProtKB/TrEMBL
      E9Q718, Q3U055
      Related
      ENSMUSP00000125373.2, ENSMUST00000160359.2
      Conserved Domains (1) summary
      smart00702
      Location:593 → 756
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. NM_011961.3 → NP_036091.2  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_036091.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2, also known as LH2a) missing a 21 aa protein segment compared to isoform 1.
      Source sequence(s)
      AC165156, AF080572, AV488215, BB644981, CF615856
      Consensus CDS
      CCDS23408.1
      UniProtKB/Swiss-Prot
      E9QM54, Q8VDT4, Q9R0B9
      UniProtKB/TrEMBL
      Q3U055
      Related
      ENSMUSP00000068611.8, ENSMUST00000070522.14
      Conserved Domains (2) summary
      smart00702
      Location:572 → 735
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      COG0463
      Location:347 → 572
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      92421828..92490481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155022.1 → XP_036010915.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X2

      Conserved Domains (1) summary
      smart00702
      Location:220 → 383
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_030244393.2 → XP_030100253.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X2

      Conserved Domains (1) summary
      smart00702
      Location:220 → 383
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    3. XM_036155021.1 → XP_036010914.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0B9.2 GenPept UniProtKB/Swiss-Prot:Q9R0B9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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