Mcat malonyl CoA:ACP acyltransferase (mitochondrial) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mcatprovided by MGI
Official Full Name: malonyl CoA:ACP acyltransferase (mitochondrial)provided by MGI
Primary source: MGI:MGI:2388651
See related: Ensembl:ENSMUSG00000048755 AllianceGenome:MGI:2388651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable [acyl-carrier-protein] S-malonyltransferase activity. Predicted to be involved in fatty acid biosynthetic process and mitochondrial small ribosomal subunit assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human MCAT (malonyl-CoA-acyl carrier protein transacylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 22.5), testis adult (RPKM 20.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 39.4 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (83430998..83439936, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (83546797..83555759, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency.
Title: Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency.
Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy.
Title: Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables [acyl-carrier-protein] S-malonyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [acyl-carrier-protein] S-malonyltransferase activity	IEA Inferred from Electronic Annotation more info
enables [acyl-carrier-protein] S-malonyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial small ribosomal subunit assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial small ribosomal subunit assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: malonyl-CoA-acyl carrier protein transacylase, mitochondrial

Names: MCT; [Acyl-carrier-protein] malonyltransferase; mitochondrial malonyltransferase

NP_001025185.1

EC 2.3.1.39

NP_001402935.1

EC 2.3.1.39

NP_001402936.1

EC 2.3.1.39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030014.3 → NP_001025185.1 malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_001025185.1

Status: VALIDATED

Source sequence(s)

AL583889

Consensus CDS

CCDS27704.1

UniProtKB/Swiss-Prot

Q4FZH0, Q8R3F5

Related

ENSMUSP00000051569.9, ENSMUST00000061882.10

Conserved Domains (1) summary

cl08282
Location:16 → 357

Acyl_transf_1; Acyl transferase domain
NM_001416006.1 → NP_001402935.1 malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

AL583889
NM_001416007.1 → NP_001402936.1 malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform 3

Status: VALIDATED

Source sequence(s)

AL583889