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    MRPL32 mitochondrial 54S ribosomal protein YmL32 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850359, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MRPL32
    Official Full Name
    mitochondrial 54S ribosomal protein YmL32
    Primary source
    SGD:S000000596
    Locus tag
    YCR003W
    See related
    AllianceGenome:SGD:S000000596; FungiDB:YCR003W; VEuPathDB:YCR003W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    bL32m
    Summary
    A structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Part of mitochondrial large ribosomal subunit. Orthologous to human MRPL32 (mitochondrial ribosomal protein L32). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MRPL32 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (118620..119171)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene septin CDC10 Neighboring gene flavodoxin-like fold family protein Neighboring gene citrate (Si)-synthase CIT2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C-terminal extension domain of Saccharomyces cerevisiae MrpL32, a homolog of ribosomal protein L32, functions in trans to support mitochondrial translation. Woogeng IN, et al. Genes Genet Syst, 2018 Jul 13. PMID 29343666
    2. Presequence-dependent folding ensures MrpL32 processing by the m-AAA protease in mitochondria. Bonn F, et al. EMBO J, 2011 May 24. PMID 21610694, Free PMC Article
    3. The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondria. Nolden M, et al. Cell, 2005 Oct 21. PMID 16239145
    4. Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species. Topf U, et al. Nat Commun, 2018 Jan 22. PMID 29358734, Free PMC Article
    5. Extended N-terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria. Grohmann L, et al. FEBS Lett, 1991 Jun 17. PMID 2060626

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Through a series of C-terminally truncated mrpl32 (mrpl32DeltaC)gene, MrpL32DeltaC derivatives exhibited temperature-sensitive (ts) growth on medium with non-fermentable carbon sources. Furthermore, the CE domain of MrpL32, expressed separately from MrpL32DeltaC, could rescue the ts phenotype of mutants by improving mitochondrial protein synthesis.
      Title: The C-terminal extension domain of Saccharomyces cerevisiae MrpL32, a homolog of ribosomal protein L32, functions in trans to support mitochondrial translation.
    2. Presequence-assisted folding of MrpL32 requires import of the MrpL32 precursor before maturation occurs, this explains the post-translocational processing by the m-AAA protease rather than co-translocational cleavage by mitochondrial processing peptidase.
      Title: Presequence-dependent folding ensures MrpL32 processing by the m-AAA protease in mitochondria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial 54S ribosomal protein YmL32
    NP_009929.1
    • Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      118620..119171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178716.1 → NP_009929.1  TPA: mitochondrial 54S ribosomal protein YmL32 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009929.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR13, P25348
      UniProtKB/TrEMBL
      B3LU75, B5VEV1, C8Z488, G2WA21, N1PAP8
      Conserved Domains (1) summary
      pfam01783
      Location:72 → 120
      Ribosomal_L32p; Ribosomal L32p protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25348.1

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