Zc3h10 zinc finger CCCH type containing 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zc3h10provided by MGI
Official Full Name: zinc finger CCCH type containing 10provided by MGI
Primary source: MGI:MGI:2143670
See related: Ensembl:ENSMUSG00000039810 AllianceGenome:MGI:2143670
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable miRNA binding activity. Predicted to be involved in negative regulation of miRNA processing and regulation of RNA splicing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Predicted to be located in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZC3H10 (zinc finger CCCH-type containing 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 16.0), ovary adult (RPKM 11.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.01 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128379429..128383877, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128543560..128548008, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction.
Title: Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction.
Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes.
Title: Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes.
our study identifies Zc3h10 as a novel mitochondrial regulator.
Title: Zc3h10 is a novel mitochondrial regulator.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI790326 (e-PCR)
- UniSTS:180130

NoName (e-PCR)
- UniSTS:236491

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger CCCH domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134003.2 → NP_598764.1 zinc finger CCCH domain-containing protein 10

See identical proteins and their annotated locations for NP_598764.1

Status: VALIDATED

Source sequence(s)

AC117232, AK050662, BB842371, BY441443

Consensus CDS

CCDS24281.1

UniProtKB/Swiss-Prot

Q8R205

Related

ENSMUSP00000042727.4, ENSMUST00000040572.10

Conserved Domains (2) summary

smart00356
Location:134 → 158

ZnF_C3H1; zinc finger

pfam06005
Location:243 → 279

ZapB; Cell division protein ZapB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

128379429..128383877 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513013.3 → XP_006513076.1 zinc finger CCCH domain-containing protein 10 isoform X1

See identical proteins and their annotated locations for XP_006513076.1

UniProtKB/Swiss-Prot

Q8R205

Conserved Domains (2) summary

smart00356
Location:134 → 158

ZnF_C3H1; zinc finger

pfam06005
Location:243 → 279

ZapB; Cell division protein ZapB