SDH4 succinate dehydrogenase membrane anchor subunit SDH4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SDH4
Official Full Name: succinate dehydrogenase membrane anchor subunit SDH4
Primary source: SGD:S000002585
Locus tag: YDR178W
See related: AllianceGenome:SGD:S000002585; FungiDB:YDR178W; VEuPathDB:YDR178W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ACN18
Summary: Contributes to succinate dehydrogenase (quinone) activity. Involved in cellular respiration. Located in mitochondrion. Part of respiratory chain complex II (succinate dehydrogenase). Used to study hypertrophic cardiomyopathy; mitochondrial complex II deficiency; and paraganglioma. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SDH4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (817950..818495)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alternative SDH subunits have been identified in the genome; S. cerevisiae contains one paralog of the Sdh3p subunit, Shh3p (YMR118c), and two paralogs of the Sdh4p subunit, Shh4p (YLR164w) and Tim18p (YOR297c).
Title: Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes.
Study provides novel insight into the metabolic effects of SDH3 and SDH4 dysfunction and highlights the effectiveness of metabolic footprinting for examining complex disorders, such as mitochondrial diseases.
Title: Mutations in the Saccharomyces cerevisiae succinate dehydrogenase result in distinct metabolic phenotypes revealed through (1)H NMR-based metabolic footprinting.
Cth2 protein recruits the Dhh1 helicase to ARE-containing mRNAs to promote SDH4 mRNA decay
Title: The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiency.
Our results support a role for Tyr-89 in the protonation of ubiquinone and argue that the generation of reactive oxygen species is not causative of tumor formation.
Title: The role of Sdh4p Tyr-89 in ubiquinone reduction by the Saccharomyces cerevisiae succinate dehydrogenase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables quinone binding	IEA Inferred from Electronic Annotation more info
contributes_to succinate dehydrogenase (quinone) activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ubiquinone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	TAS Traceable Author Statement more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial envelope	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex II (succinate dehydrogenase)	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex II (succinate dehydrogenase)	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: succinate dehydrogenase membrane anchor subunit SDH4

NP_010463.1

Membrane anchor subunit of succinate dehydrogenase (SDH); involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; has similarity to human SDH subunit D (SDHD), which is implicated in paraganglioma

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

817950..818495

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180485.1 → NP_010463.1 TPA: succinate dehydrogenase membrane anchor subunit SDH4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010463.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSG0, P37298

UniProtKB/TrEMBL

A6ZYD6, B3LGA5, C7GN19, C8Z591, G2WAS6, N1P4W3

Conserved Domains (1) summary

pfam05328
Location:34 → 167

CybS; succinate dehydrogenase cytochrome B small subunit