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    PEA2 Pea2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856892, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PEA2
    Official Full Name
    Pea2p
    Primary source
    SGD:S000000951
    Locus tag
    YER149C
    See related
    AllianceGenome:SGD:S000000951; FungiDB:YER149C; VEuPathDB:YER149C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DFG9; PPF2
    Summary
    Enables myosin V binding activity. Involved in several processes, including bipolar cellular bud site selection; budding cell apical bud growth; and pseudohyphal growth. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. Part of polarisome. Is active in site of polarized growth. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PEA2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (466208..467470, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene cohesin-loading factor complex subunit SCC4 Neighboring gene TATA-binding protein Neighboring gene Spi1p Neighboring gene tRNA-Val

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae MATa mutant cells defective in pointed projection formation in response to alpha-factor at high concentrations. Yorihuzi T, et al. Yeast, 1994 May. PMID 7941743
    2. Pea2 protein of yeast is localized to sites of polarized growth and is required for efficient mating and bipolar budding. Valtz N, et al. J Cell Biol, 1996 Nov. PMID 8909546, Free PMC Article
    3. Modular coherence of protein dynamics in yeast cell polarity system. Gao JT, et al. Proc Natl Acad Sci U S A, 2011 May 3. PMID 21502521, Free PMC Article
    4. Importance of polarisome proteins in reorganization of actin cytoskeleton at low pH in Saccharomyces cerevisiae. Motizuki M, et al. J Biochem, 2009 Nov. PMID 19633059
    5. Yeast formins regulate cell polarity by controlling the assembly of actin cables. Sagot I, et al. Nat Cell Biol, 2002 Jan. PMID 11740491

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables myosin V binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bipolar cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in budding cell apical bud growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in budding cell apical bud growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell morphogenesis involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in filamentous growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of polarisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pea2p
    NP_011076.1
    • Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation, filamentous differentiation; involved in Bni1p localization at sites of polarized growth, controlling polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at bud tip to regulate ER inheritance; role in Ca2+ influx, cell fusion; S288C allele encoding Leu409 rather than Met linked with non-invasion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      466208..467470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179039.1 → NP_011076.1  TPA: Pea2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011076.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM56, P40091, Q70DC9, Q70DD1, Q70DD2, Q70DD3, Q70DD4, Q70DD6, Q70DD7, Q70DD8
      UniProtKB/TrEMBL
      A6ZRA6, B3LRR2, C7GQ47, G2WD36, N1PA61
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40091.1

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