APE4 aspartyl aminopeptidase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: APE4
Official Full Name: aspartyl aminopeptidase
Primary source: SGD:S000001155
Locus tag: YHR113W
See related: AllianceGenome:SGD:S000001155; FungiDB:YHR113W; VEuPathDB:YHR113W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables aminopeptidase activity. Involved in proteolysis. Located in fungal-type vacuole lumen. Orthologous to human DNPEP (aspartyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

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cytosolic Ape4 is redistributed to the vacuole when yeast cells need more active vacuolar degradation.
Title: Aspartyl aminopeptidase is imported from the cytoplasm to the vacuole by selective autophagy in Saccharomyces cerevisiae.
Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells
Title: Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables aminopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in fungal-type vacuole	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole lumen	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar lumen	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

NP_011981.1

Cytoplasmic aspartyl aminopeptidase with possible vacuole function; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via CVT pathway; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms 12-subunit homo-oligomer; M18 metalloprotease family

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The following sections contain reference sequences that belong to a specific genome build. Explain