REX4 putative 3'-5' exonuclease [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: REX4
Official Full Name: putative 3'-5' exonuclease
Primary source: SGD:S000005440
Locus tag: YOL080C
See related: AllianceGenome:SGD:S000005440; FungiDB:YOL080C; VEuPathDB:YOL080C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable 3'-5' exonuclease activity. Involved in rRNA processing and ribosomal large subunit assembly. Located in nucleolus. Orthologous to several human genes including REXO4 (REX4 homolog, 3'-5' exonuclease). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

data link three RNA catabolic enzymes, Rex4p, Rnt1p, and Dbr1p, to ITS1 processing and the relative production of 5.8SS and 5.8SL rRNA
Title: The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction with trans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiae pre-rRNA.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosomal large subunit assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014561.1

Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly

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The following sections contain reference sequences that belong to a specific genome build. Explain