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    SLD5 DNA replication protein SLD5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852100, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLD5
    Official Full Name
    DNA replication protein SLD5
    Primary source
    SGD:S000002897
    Locus tag
    YDR489W
    See related
    AllianceGenome:SGD:S000002897; FungiDB:YDR489W; VEuPathDB:YDR489W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDC105
    Summary
    Involved in DNA-templated DNA replication and double-strand break repair via break-induced replication. Part of CMG complex; GINS complex; and replication fork protection complex. Orthologous to human GINS4 (GINS complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLD5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1431012..1431896)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 Neighboring gene dynein intermediate chain Neighboring gene serine/threonine protein kinase PKH1 Neighboring gene PAQR-type receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Kanemaki M, et al. Nature, 2003 Jun 12. PMID 12768207
    2. The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress. Fumasoni M, et al. Elife, 2020 Feb 11. PMID 32043971, Free PMC Article
    3. A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome. Simon AC, et al. Nature, 2014 Jun 12. PMID 24805245, Free PMC Article
    4. Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Kamimura Y, et al. Mol Cell Biol, 1998 Oct. PMID 9742127, Free PMC Article
    5. Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome. Samora CP, et al. Mol Cell, 2016 Aug 4. PMID 27397686, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via break-induced replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA replication preinitiation complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of DNA replication preinitiation complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of replication fork protection complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication protein SLD5
    NP_010777.3
    • Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1431012..1431896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180797.3 → NP_010777.3  TPA: DNA replication protein SLD5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010777.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTB2, Q03406, Q6Q558
      UniProtKB/TrEMBL
      A6ZZ78, B3LFH7, C7GKS7, C8Z647, G2WBL8, N1P7E9
      Conserved Domains (1) summary
      COG5086
      Location:1 → 294
      COG5086; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03406.1

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