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    AIM10 putative proline--tRNA ligase AIM10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856820, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIM10
    Official Full Name
    putative proline--tRNA ligase AIM10
    Primary source
    SGD:S000000889
    Locus tag
    YER087W
    See related
    AllianceGenome:SGD:S000000889; FungiDB:YER087W; VEuPathDB:YER087W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AIM10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (330576..332306)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene threonine ammonia-lyase ILV1 Neighboring gene Arf family guanine nucleotide exchange factor SBH1 Neighboring gene Dot6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of a putative prolyl-tRNA synthetase (CaPRS) gene from Candida albicans. Sentandreu M, et al. Yeast, 1997 Nov. PMID 9392082
    2. A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia. Bunjun S, et al. Proc Natl Acad Sci U S A, 2000 Nov 21. PMID 11078517, Free PMC Article
    3. Restoring species-specific posttransfer editing activity to a synthetase with a defunct editing domain. SternJohn J, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17283340, Free PMC Article
    4. Cysteine activation is an inherent in vitro property of prolyl-tRNA synthetases. Ahel I, et al. J Biol Chem, 2002 Sep 20. PMID 12130657
    5. The COG database: a tool for genome-scale analysis of protein functions and evolution. Tatusov RL, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592175, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on a tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in prolyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prolyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative proline--tRNA ligase AIM10
    NP_011010.1
    • Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      330576..332306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178978.1 → NP_011010.1  TPA: putative proline--tRNA ligase AIM10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011010.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLZ3, P39965
      UniProtKB/TrEMBL
      A6ZR42, B3LRK4, C8Z7A0, G2WCX7, N1PA48
      Conserved Domains (1) summary
      COG0442
      Location:9 → 530
      ProS; Prolyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39965.1

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