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    UBC6 E2 ubiquitin-conjugating protein UBC6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856837, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UBC6
    Official Full Name
    E2 ubiquitin-conjugating protein UBC6
    Primary source
    SGD:S000000902
    Locus tag
    YER100W
    See related
    AllianceGenome:SGD:S000000902; FungiDB:YER100W; VEuPathDB:YER100W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DOA2
    Summary
    Enables ubiquitin-protein transferase activity. Involved in ERAD pathway; protein monoubiquitination; and protein polyubiquitination. Located in endoplasmic reticulum membrane. Orthologous to human UBE2J2 (ubiquitin conjugating enzyme E2 J2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UBC6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (359562..360314)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-specific protease UBP9 Neighboring gene ribose phosphate diphosphokinase subunit PRS2 Neighboring gene Ast2p Neighboring gene ribosomal 40S subunit protein S8B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein. Mayer TU, et al. EMBO J, 1998 Jun 15. PMID 9628862, Free PMC Article
    2. The transmembrane domain of a carboxyl-terminal anchored protein determines localization to the endoplasmic reticulum. Yang M, et al. J Biol Chem, 1997 Jan 17. PMID 8999888
    3. Endoplasmic reticulum and inner nuclear membrane ubiquitin-conjugating enzymes Ubc6 and Ubc7 confer resistance to hygromycin B in Saccharomyces cerevisiae. Owutey SL, et al. MicroPubl Biol, 2024. PMID 39139584, Free PMC Article
    4. Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast. Jakob CA, et al. EMBO Rep, 2001 May. PMID 11375935, Free PMC Article
    5. Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair. Gilon T, et al. Mol Cell Biol, 2000 Oct. PMID 10982838, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sequential poly-ubiquitylation by specialized conjugating enzymes Ubc6 and Ubc7 expands the versatility of a quality control ubiquitin ligase Doa10.
      Title: Sequential Poly-ubiquitylation by Specialized Conjugating Enzymes Expands the Versatility of a Quality Control Ubiquitin Ligase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein monoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E2 ubiquitin-conjugating protein UBC6
    NP_011026.3
    • Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      359562..360314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178991.3 → NP_011026.3  TPA: E2 ubiquitin-conjugating protein UBC6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011026.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM07, P33296
      UniProtKB/TrEMBL
      A6ZR56, B3LRL8, B5VHM6, C7GVH2, C8Z7B8, G2WD23, N1PA51
      Conserved Domains (1) summary
      COG5078
      Location:1 → 154
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33296.1

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