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    SSA4 Hsp70 family chaperone SSA4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856840, updated on 17-Dec-2024

    Summary

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    Official Symbol
    SSA4
    Official Full Name
    Hsp70 family chaperone SSA4
    Primary source
    SGD:S000000905
    Locus tag
    YER103W
    See related
    AllianceGenome:SGD:S000000905; FungiDB:YER103W; VEuPathDB:YER103W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YG107
    Summary
    Enables unfolded protein binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane, translocation and protein folding. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); neurodegenerative disease (multiple); and schizophrenia (multiple). Orthologous to several human genes including HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SSA4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (364589..366517)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Ast2p Neighboring gene ribosomal 40S subunit protein S8B Neighboring gene Rtt105p Neighboring gene Nup157p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and regulation of the SSA4 HSP70 gene of Saccharomyces cerevisiae. Boorstein WR, et al. J Biol Chem, 1990 Nov 5. PMID 2121731
    2. Regulation of mRNA export in response to stress in Saccharomyces cerevisiae. Saavedra C, et al. Genes Dev, 1996 Jul 1. PMID 8682292
    3. Expression profiling by oligonucleotide microarrays spotted on coated polymer slides. Nielsen PS, et al. J Biotechnol, 2005 Mar 16. PMID 15664076
    4. Starvation promotes nuclear accumulation of the hsp70 Ssa4p in yeast cells. Chughtai ZS, et al. J Biol Chem, 2001 Jun 8. PMID 11279056
    5. Transient intracellular acidification regulates the core transcriptional heat shock response. Triandafillou CG, et al. Elife, 2020 Aug 7. PMID 32762843, Free PMC Article

    See all (146) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Yeast Hsp70 Cochaperone Ydj1 Regulates Functional Distinction of Ssa Hsp70s in the Hsp90 Chaperoning Pathway.
      Title: The Yeast Hsp70 Cochaperone Ydj1 Regulates Functional Distinction of Ssa Hsp70s in the Hsp90 Chaperoning Pathway.
    2. Differential role of cytosolic Hsp70s in longevity assurance and protein quality control.
      Title: Differential role of cytosolic Hsp70s in longevity assurance and protein quality control.
    3. results indicated that histone acetylation was required for the transcriptional activation of SSA3 and SSA4
      Title: Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast.
    4. Ssa4p nuclear exporter was identified as Msn5p/Kap142p that promotes nuclear export of Ssa4p and relocates in response to stress.
      Title: The carrier Msn5p/Kap142p promotes nuclear export of the hsp70 Ssa4p and relocates in response to stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Hsp70 family chaperone SSA4
    NP_011029.3
    • Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; translocates to the nucleus under Cd2+ stress to mediate tolerance by regulating VHS1 expression; cytoplasmic protein that concentrates in nuclei upon starvation; member of the HSP70 family; SSA4 has a paralog, SSA3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      364589..366517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178994.3 → NP_011029.3  TPA: Hsp70 family chaperone SSA4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011029.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM10, P22202
      UniProtKB/TrEMBL
      A6ZR59, B3LRM1, C7GS82, N1P731
      Conserved Domains (1) summary
      PTZ00009
      Location:4 → 642
      PTZ00009; heat shock 70 kDa protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22202.3

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