GDI1 Gdi1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GDI1
Official Full Name: Gdi1p
Primary source: SGD:S000000938
Locus tag: YER136W
See related: AllianceGenome:SGD:S000000938; FungiDB:YER136W; VEuPathDB:YER136W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SEC19
Summary: Enables Rab GDP-dissociation inhibitor activity. Involved in vesicle-mediated transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Used to study cancer. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability; non-syndromic X-linked intellectual disability 41; and psychotic disorder. Orthologous to human GDI1 (GDP dissociation inhibitor 1) and GDI2 (GDP dissociation inhibitor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

GDI1 protein is involved in Zn efflux via small vesicle trafficking and contributes to the control of cytoplasmic Zn content.
Title: Possible involvement of GDI1 protein, a GDP dissociation inhibitor related to vesicle transport, in an amelioration of zinc toxicity in Saccharomyces cerevisiae.
structural analysis of the GDP dissociation inhibitor rab membrane extraction mechanism through Rab.GDI and Rab.MRS6 complexes
Title: A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables Rab GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rab GDP-dissociation inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables Rab GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

NP_011062.1

GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins