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    HNM1 Hnm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852803, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HNM1
    Official Full Name
    Hnm1p
    Primary source
    SGD:S000003045
    Locus tag
    YGL077C
    See related
    AllianceGenome:SGD:S000003045; FungiDB:YGL077C; VEuPathDB:YGL077C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CTR1
    Summary
    Enables (R)-carnitine transmembrane transporter activity; choline transmembrane transporter activity; and ethanolamine transmembrane transporter activity. Involved in amino-acid betaine transport; choline transport; and ethanolamine transport. Located in cell periphery and endoplasmic reticulum. Used to study proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HNM1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (362225..363916, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Kxd1p Neighboring gene RNA-dependent ATPase DBP3 Neighboring gene ribosomal 60S subunit protein L7A Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypersaline stress induces the turnover of phosphatidylcholine and results in the synthesis of the renal osmoprotectant glycerophosphocholine in Saccharomyces cerevisiae. Kiewietdejonge A, et al. FEMS Yeast Res, 2006 Mar. PMID 16487344
    2. Sensitivity to nitrogen mustard in Saccharomyces cerevisiae is independently determined by regulated choline permease and DNA repair. Li Z, et al. Mutat Res, 1994 Sep. PMID 7520996
    3. 2-hydroxyethylhydrazine as a potent inhibitor of phospholipid methylation in yeast. Nikawa J, et al. Biochim Biophys Acta, 1983 Apr 13. PMID 6338930
    4. Cloning of a gene encoding choline transport in Saccharomyces cerevisiae. Nikawa J, et al. J Bacteriol, 1986 Apr. PMID 3514579, Free PMC Article
    5. Primary structure of the yeast choline transport gene and regulation of its expression. Nikawa J, et al. J Biol Chem, 1990 Sep 15. PMID 2203793

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability
      Title: Choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables (R)-carnitine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables choline transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ethanolamine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables gamma-aminobutyric acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in (R)-carnitine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in (R)-carnitine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in choline transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ethanolamine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine betaine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Hnm1p
    NP_011438.1
    • Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; human FLVCR2 (MFSD7c), a choline transporter involved in Fowler syndrome, can complement the yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      362225..363916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180942.1 → NP_011438.1  TPA: Hnm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011438.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU67, P19807
      UniProtKB/TrEMBL
      A6ZUA2, B3LHE3, C7GW38, C8Z8H0, G2WE22, N1P9Q6
      Conserved Domains (1) summary
      TIGR00907
      Location:45 → 521
      2A0304; amino acid permease (GABA permease)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19807.1

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