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    VOA1 Voa1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852998, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VOA1
    Official Full Name
    Voa1p
    Primary source
    SGD:S000003338
    Locus tag
    YGR106C
    See related
    AllianceGenome:SGD:S000003338; FungiDB:YGR106C; VEuPathDB:YGR106C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein-containing complex assembly. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VOA1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (698989..699786, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Srb5p Neighboring gene Vma21p Neighboring gene tRNA-Leu Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase V(o) Proton Channel. Roh SH, et al. Mol Cell, 2018 Mar 15. PMID 29526695, Free PMC Article
    2. Big1 is a newly identified autophagy regulator that is critical for a fully functional V-ATPase. Lei Y, et al. Mol Biol Cell, 2024 Nov 1. PMID 39259764, Free PMC Article
    3. ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation. Jansen EJ, et al. Nat Commun, 2016 May 27. PMID 27231034, Free PMC Article
    4. Voa1p functions in V-ATPase assembly in the yeast endoplasmic reticulum. Ryan M, et al. Mol Biol Cell, 2008 Dec. PMID 18799613, Free PMC Article
    5. Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis. Bar-Yosef H, et al. Sci Rep, 2017 Jul 18. PMID 28720834, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Voa1p
    NP_011620.1
    • ER protein that functions in assembly of the V0 sector of V-ATPase; functions with other assembly factors; null mutation enhances the vacuolar ATPase (V-ATPase) deficiency of a vma21 mutant impaired in endoplasmic reticulum (ER) retrieval

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      698989..699786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181235.1 → NP_011620.1  TPA: Voa1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUN8, P53262
      UniProtKB/TrEMBL
      A6ZV88, B3LIC0, B5VJ52, C7GWV7, G2WEJ1, N1P405
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53262.1

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