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    ENP2 ribosome biosynthesis protein ENP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853048, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ENP2
    Official Full Name
    ribosome biosynthesis protein ENP2
    Primary source
    SGD:S000003377
    Locus tag
    YGR145W
    See related
    AllianceGenome:SGD:S000003377; FungiDB:YGR145W; VEuPathDB:YGR145W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of small-subunit processome. Orthologous to human NOL10 (nucleolar protein 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ENP2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (781767..783890)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene thiamine thiazole synthase Neighboring gene Ecl1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for short-patch mismatch repair in Saccharomyces cerevisiae. Coïc E, et al. EMBO J, 2000 Jul 3. PMID 10880453, Free PMC Article
    2. The sequence of a 27 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2, NSR1 genes and ten new open reading frames. Skala J, et al. Yeast, 1995 Nov. PMID 8585325
    3. Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration. Cheng J, et al. Mol Cell, 2019 Sep 19. PMID 31378463
    4. Nucleolar proteins Bfr2 and Enp2 interact with DEAD-box RNA helicase Dbp4 in two different complexes. Soltanieh S, et al. Nucleic Acids Res, 2014 Mar. PMID 24357410, Free PMC Article
    5. Cryo-EM structure of 90S small ribosomal subunit precursors in transition states. Du Y, et al. Science, 2020 Sep 18. PMID 32943522

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosome biosynthesis protein ENP2
    NP_011661.2
    • Component of the SSU; required for pre-18S rRNA processing, biogenesis of the small ribosomal subunit; interacts with U3 snoRNA, Mpp10p and Bfr2p; contains WD repeats, and has homology to Spb1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      781767..783890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181274.2 → NP_011661.2  TPA: ribosome biosynthesis protein ENP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011661.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUS5, P48234
      UniProtKB/TrEMBL
      A6ZUF7, B3LI85, B5VJ89, C7GSX7, N1P5Y2
      Conserved Domains (3) summary
      COG2319
      Location:1 → 311
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:183 → 225
      7WD40; WD40 repeat [structural motif]
      pfam08159
      Location:479 → 507
      NUC153; NUC153 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48234.2

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