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    SAM35 SAM complex subunit SAM35 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAM35
    Official Full Name
    SAM complex subunit SAM35
    Primary source
    SGD:S000001125
    Locus tag
    YHR083W
    See related
    AllianceGenome:SGD:S000001125; FungiDB:YHR083W; VEuPathDB:YHR083W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FMP20; TOB38; TOM38
    Summary
    Involved in mitochondrial outer membrane translocase complex assembly and protein insertion into mitochondrial outer membrane. Located in mitochondrial outer membrane. Part of SAM complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAM35 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (272627..273616)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Lrp1p Neighboring gene putative serine/threonine protein kinase KSP1 Neighboring gene homeodomain family transcription factor STE12 Neighboring gene Ipi1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. Milenkovic D, et al. J Biol Chem, 2004 May 21. PMID 15067005
    2. Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. Waizenegger T, et al. EMBO Rep, 2004 Jul. PMID 15205677, Free PMC Article
    3. The C-terminal domain of Fcj1 is required for formation of crista junctions and interacts with the TOB/SAM complex in mitochondria. Körner C, et al. Mol Biol Cell, 2012 Jun. PMID 22496419, Free PMC Article
    4. Membrane protein insertion through a mitochondrial β-barrel gate. Höhr AIC, et al. Science, 2018 Jan 19. PMID 29348211, Free PMC Article
    5. Assembly of the TOB complex of mitochondria. Habib SJ, et al. J Biol Chem, 2005 Feb 25. PMID 15590639

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Assembly of newly synthesized Tob55 into preexisting TOB complexes depended on Tob38 but did not require Mas37
      Title: Assembly of the TOB complex of mitochondria.
    2. Tob38 has a crucial function in the biogenesis of beta-barrel proteins of mitochondria
      Title: Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial outer membrane translocase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAM complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SAM complex subunit SAM35
    NP_011951.1
    • Component of the sorting and assembly machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      272627..273616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179213.1 → NP_011951.1  TPA: SAM complex subunit SAM35 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011951.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL34, P14693
      UniProtKB/TrEMBL
      A6ZSZ2, N1P126
      Conserved Domains (1) summary
      pfam10806
      Location:5 → 133
      SAM35; subunit of SAM coomplex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14693.2

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