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    HXT5 hexose transporter HXT5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856496, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HXT5
    Official Full Name
    hexose transporter HXT5
    Primary source
    SGD:S000001138
    Locus tag
    YHR096C
    See related
    AllianceGenome:SGD:S000001138; FungiDB:YHR096C; VEuPathDB:YHR096C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-glucose transmembrane transporter activity; fructose transmembrane transporter activity; and mannose transmembrane transporter activity. Involved in D-glucose transmembrane transport. Located in plasma membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HXT5 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (294669..296447, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Aht1p Neighboring gene hexose transporter HXT1 Neighboring gene Pal2p Neighboring gene Sfb3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic analysis of cytosolic glucose and ATP levels in yeast using optical sensors. Bermejo C, et al. Biochem J, 2010 Dec 1. PMID 20854260, Free PMC Article
    2. Degradation of the hexose transporter Hxt5p in Saccharomyces cerevisiae. van Suylekom D, et al. Biol Cell, 2007 Jan. PMID 16928197
    3. HXT5 expression is under control of STRE and HAP elements in the HXT5 promoter. Verwaal R, et al. Yeast, 2004 Jul 15. PMID 15282798
    4. HXT5 expression is determined by growth rates in Saccharomyces cerevisiae. Verwaal R, et al. Yeast, 2002 Sep 15. PMID 12210898
    5. Functional analysis of the hexose transporter homologue HXT5 in Saccharomyces cerevisiae. Diderich JA, et al. Yeast, 2001 Dec. PMID 11748728

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-glucose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mannose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hexose transporter HXT5
    NP_011964.1
    • Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      294669..296447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179226.1 → NP_011964.1  TPA: hexose transporter HXT5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011964.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL46, P38695
      UniProtKB/TrEMBL
      A6ZT04, B3LSL1, C7GLY4, C8Z9N9, E9P9H1, N1P9E5
      Conserved Domains (1) summary
      pfam00083
      Location:89 → 549
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38695.1

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