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    LSM12 Lsm12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LSM12
    Official Full Name
    Lsm12p
    Primary source
    SGD:S000001163
    Locus tag
    YHR121W
    See related
    AllianceGenome:SGD:S000001163; FungiDB:YHR121W; VEuPathDB:YHR121W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in RNA metabolic process. Located in cytoplasmic stress granule. Orthologous to human LSM12 (LSM12 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LSM12 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (352756..353319)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene histone methyltransferase SET1 Neighboring gene mismatch repair ATPase MSH1 Neighboring gene iron-sulfur cluster assembly protein CIA2 Neighboring gene bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nst1, Densely Associated to P-Body in the Post-Exponential Phases of Saccharomyces cerevisiae, Shows an Intrinsic Potential of Producing Liquid-Like Condensates of P-Body Components in Cells. Choi YJ, et al. Int J Mol Sci, 2022 Feb 24. PMID 35269643, Free PMC Article
    2. Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae. Swisher KD, et al. PLoS One, 2010 Apr 2. PMID 20368989, Free PMC Article
    3. The Zymomonas mobilis regulator hfq contributes to tolerance against multiple lignocellulosic pretreatment inhibitors. Yang S, et al. BMC Microbiol, 2010 May 7. PMID 20459639, Free PMC Article
    4. Pbp1 is involved in Ccr4- and Khd1-mediated regulation of cell growth through association with ribosomal proteins Rpl12a and Rpl12b. Kimura Y, et al. Eukaryot Cell, 2013 Jun. PMID 23563484, Free PMC Article
    5. Lsm12 Mediates Deubiquitination of DNA Polymerase η To Help Saccharomyces cerevisiae Resist Oxidative Stress. Yao R, et al. Appl Environ Microbiol, 2019 Jan 1. PMID 30366994, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lsm12 is a novel regulator mediating Poleta deubiquitination that regulates its recruitment in response to DNA damage induced by oxidative stress.
      Title: Lsm12 Mediates Deubiquitination of DNA Polymerase η To Help Saccharomyces cerevisiae Resist Oxidative Stress.
    2. Pbp4 and Lsm12 proteins did not dramatically affect the formation of stress granules or P-bodies.
      Title: Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA metabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in RNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lsm12p
    NP_011989.1
    • hypothetical protein that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      352756..353319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179251.1 → NP_011989.1  TPA: Lsm12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011989.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL71, P38828
      UniProtKB/TrEMBL
      A6ZT29, B3LSN6, B5VK56, C7GR67, C8Z9R4, G2WFJ5, N1P299
      Conserved Domains (1) summary
      smart00995
      Location:80 → 170
      AD; Anticodon-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38828.1

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