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    S-formylglutathione hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853377, updated on 9-Dec-2024

    Summary

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    Official Full Name
    S-formylglutathione hydrolase
    Primary source
    SGD:S000003604
    Locus tag
    YJL068C
    See related
    AllianceGenome:SGD:S000003604; FungiDB:YJL068C; VEuPathDB:YJL068C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables S-formylglutathione hydrolase activity. Involved in formaldehyde catabolic process. Located in cytosol. Orthologous to human ESD (esterase D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (313016..313915, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene metallo-dependent hydrolase superfamily protein Neighboring gene Utp18p Neighboring gene Mpm1p Neighboring gene Dls1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and properties of an esterase from the yeast Saccharomyces cerevisiae and identification of the encoding gene. Degrassi G, et al. Appl Environ Microbiol, 1999 Aug. PMID 10427036, Free PMC Article
    2. Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase. Legler PM, et al. Biochemistry, 2008 Sep 9. PMID 18707125
    3. A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: evidence for an oxidation sensitive motif. Legler PM, et al. Arch Biochem Biophys, 2012 Dec 1. PMID 22906720
    4. Disruption of six ORFs on Saccharomyces cerevisiae chromosome X: the YJL069c gene of unknown function is essential to cell viability. Vandenbol M, et al. Yeast, 1999 Sep 30. PMID 10509023
    5. Multiplex assay for condition-dependent changes in protein-protein interactions. Schlecht U, et al. Proc Natl Acad Sci U S A, 2012 Jun 5. PMID 22615397, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase
      Title: Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-formylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-formylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-formylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in formaldehyde catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formaldehyde catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    S-formylglutathione hydrolase
    NP_012467.1
    • Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      313016..313915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181501.1 → NP_012467.1  TPA: S-formylglutathione hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012467.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWB5, P40363
      UniProtKB/TrEMBL
      A6ZPQ5, B3LQ43, B5VLB1, C7GR45, C8ZBE5, N1P0U8
      Conserved Domains (1) summary
      cl21494
      Location:2 → 296
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40363.1

    Gene LinkOut

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