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    SFC1 Sfc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853558, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SFC1
    Official Full Name
    Sfc1p
    Primary source
    SGD:S000003856
    Locus tag
    YJR095W
    See related
    AllianceGenome:SGD:S000003856; FungiDB:YJR095W; VEuPathDB:YJR095W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ACR1
    Summary
    Enables succinate:fumarate antiporter activity. Involved in fumarate transport and succinate transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SFC1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (609773..610741)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L43B Neighboring gene aldo-keto reductase superfamily protein Neighboring gene Jjj3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ACR1, a gene encoding a protein related to mitochondrial carriers, is essential for acetyl-CoA synthetase activity in Saccharomyces cerevisiae. Fernández M, et al. Mol Gen Genet, 1994 Mar. PMID 7908717
    2. Multiple regulatory elements control the expression of the yeast ACR1 gene. Redruello B, et al. FEBS Lett, 1999 Feb 26. PMID 10094465
    3. Identification of the yeast ACR1 gene product as a succinate-fumarate transporter essential for growth on ethanol or acetate. Palmieri L, et al. FEBS Lett, 1997 Nov 3. PMID 9395087
    4. Identification of an Arabidopsis mitochondrial succinate-fumarate translocator. Catoni E, et al. FEBS Lett, 2003 Jan 16. PMID 12527366
    5. Biochemical and functional characterization of a mitochondrial citrate carrier in Arabidopsis thaliana. Brito DS, et al. Biochem J, 2020 May 15. PMID 32329787

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biochemical and functional characterization of a mitochondrial citrate carrier in Arabidopsis thaliana.
      Title: Biochemical and functional characterization of a mitochondrial citrate carrier in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables succinate:fumarate antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate:fumarate antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fumarate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fumarate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in succinate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in succinate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sfc1p
    NP_012629.1
    • Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      609773..610741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181753.1 → NP_012629.1  TPA: Sfc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012629.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWR4, P33303
      UniProtKB/TrEMBL
      A6ZQ51, B3LQI0, C7GMB2, C8ZBP2, G2WH98, N1P169
      Conserved Domains (1) summary
      pfam00153
      Location:210 → 304
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33303.2

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