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    URA8 CTP synthase URA8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853567, updated on 9-Dec-2024

    Summary

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    Official Symbol
    URA8
    Official Full Name
    CTP synthase URA8
    Primary source
    SGD:S000003864
    Locus tag
    YJR103W
    See related
    AllianceGenome:SGD:S000003864; FungiDB:YJR103W; VEuPathDB:YJR103W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables CTP synthase activity. Involved in CTP biosynthetic process. Located in cytoophidium. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1) and CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See URA8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (620754..622490)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein RSM26 Neighboring gene ESCRT-II subunit protein VPS25 Neighboring gene superoxide dismutase SOD1 Neighboring gene adenosine kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential biochemical regulation of the URA7- and URA8-encoded CTP synthetases from Saccharomyces cerevisiae. Nadkarni AK, et al. J Biol Chem, 1995 Oct 20. PMID 7559626
    2. Regulation of phospholipid biosynthesis in Saccharomyces cerevisiae by CTP. McDonough VM, et al. J Biol Chem, 1995 Aug 11. PMID 7642527
    3. Phosphorylation of CTP synthetase from Saccharomyces cerevisiae by protein kinase C. Yang WL, et al. J Biol Chem, 1995 Jun 23. PMID 7797479, Free PMC Article
    4. Use of synthetic lethal mutants to clone and characterize a novel CTP synthetase gene in Saccharomyces cerevisiae. Ozier-Kalogeropoulos O, et al. Mol Gen Genet, 1994 Feb. PMID 8121398
    5. Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in Saccharomyces cerevisiae. Park TS, et al. J Biol Chem, 2003 Jun 6. PMID 12670958

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CTP synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CTP synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CTP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoophidium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoophidium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    CTP synthase URA8
    NP_012637.4
    • Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      620754..622490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181761.4 → NP_012637.4  TPA: CTP synthase URA8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012637.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZQ59, D6VWS2, P38627
      UniProtKB/TrEMBL
      N1P3L8
      Conserved Domains (1) summary
      TIGR00337
      Location:1 → 557
      PyrG; CTP synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38627.4

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