U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HSK3 Hsk3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853719, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HSK3
    Official Full Name
    Hsk3p
    Primary source
    SGD:S000028421
    Locus tag
    YKL138C-A
    See related
    AllianceGenome:SGD:S000028421; FungiDB:YKL138C-A; VEuPathDB:YKL138C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to microtubule plus-end binding activity. Involved in attachment of spindle microtubules to kinetochore; positive regulation of attachment of spindle microtubules to kinetochore; and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HSK3 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (184803..185012, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene sterol esterase Neighboring gene cyclin-dependent serine/threonine protein kinase CTK1 Neighboring gene mitochondrial 54S ribosomal protein YmL31 Neighboring gene Cmc1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A method for reverse interactome analysis: High-resolution mapping of interdomain interaction network in Dam1 complex and its specific disorganization based on the interaction domain expression. Ikeuchi A, et al. Biotechnol Prog, 2010 Jul-Aug. PMID 20730753
    2. Subunit organization in the Dam1 kinetochore complex and its ring around microtubules. Ramey VH, et al. Mol Biol Cell, 2011 Nov. PMID 21965284, Free PMC Article
    3. The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement. Asbury CL, et al. Proc Natl Acad Sci U S A, 2006 Jun 27. PMID 16777964, Free PMC Article
    4. Protein arms in the kinetochore-microtubule interface of the yeast DASH complex. Miranda JJ, et al. Mol Biol Cell, 2007 Jul. PMID 17460120, Free PMC Article
    5. Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation. Gestaut DR, et al. Nat Cell Biol, 2008 Apr. PMID 18364702, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe two novel subunits of DASH, Hsk2 and Hsk3 (helper of Ask1), and suggest that Hsk3 acts to incorporate Ask1 into the DASH complex.
      Title: Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in attachment of spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DASH complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Hsk3p
    NP_690844.1
    • Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      184803..185012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184513.1 → NP_690844.1  TPA: Hsk3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_690844.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX58, P69852
      UniProtKB/TrEMBL
      A6ZZI3, B3LQW2, C7GVH8, C8ZC37, G2WHQ0, N1NZQ1
      Conserved Domains (1) summary
      pfam08227
      Location:6 → 52
      DASH_Hsk3; DASH complex subunit Hsk3 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P69852.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools