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    ADD66 Add66p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ADD66
    Official Full Name
    Add66p
    Primary source
    SGD:S000001689
    Locus tag
    YKL206C
    See related
    AllianceGenome:SGD:S000001689; FungiDB:YKL206C; VEuPathDB:YKL206C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PBA2; POC2
    Summary
    Involved in proteasome assembly. Located in cytosol. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 4. Orthologous to human PSMG2 (proteasome assembly chaperone 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ADD66 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (49006..49809, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Cbt1p Neighboring gene Emc3p Neighboring gene Ran GTPase-binding protein LOS1 Neighboring gene Eap1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ADD66, a gene involved in the endoplasmic reticulum-associated degradation of alpha-1-antitrypsin-Z in yeast, facilitates proteasome activity and assembly. Scott CM, et al. Mol Biol Cell, 2007 Oct. PMID 17634286, Free PMC Article
    2. Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function. Stadtmueller BM, et al. J Biol Chem, 2012 Oct 26. PMID 22930756, Free PMC Article
    3. Mechanism of proteasome gate modulation by assembly chaperones Pba1 and Pba2. Schnell HM, et al. J Biol Chem, 2022 May. PMID 35398095, Free PMC Article
    4. Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis. Schnell HM, et al. Nat Struct Mol Biol, 2021 May. PMID 33846632, Free PMC Article
    5. Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation. Palmer EA, et al. J Cell Sci, 2003 Jun 1. PMID 12711700

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of proteasome gate modulation by assembly chaperones Pba1 and Pba2.
      Title: Mechanism of proteasome gate modulation by assembly chaperones Pba1 and Pba2.
    2. Ump1 and Pba1-Pba2 promote efficient biogenesis of 20S proteasome core particles from its subunits via 15S intermediates
      Title: Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperone.
    3. ADD66 encodes an approximately 30-kDa soluble, cytosolic protein and that the chymotrypsin-like activity of the proteasome is reduced in add66Delta mutants.
      Title: ADD66, a gene involved in the endoplasmic reticulum-associated degradation of alpha-1-antitrypsin-Z in yeast, facilitates proteasome activity and assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteasome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Add66p
    NP_012716.1
    • Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      49006..49809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179771.1 → NP_012716.1  TPA: Add66p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012716.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWZ7, P36040
      UniProtKB/TrEMBL
      A7A083, B3LQQ3, B5VLW0, C7GJ07, C8ZBX4, G2WHI8, N1P7X9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36040.1

    Gene LinkOut

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