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    PEX9 Pex9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PEX9
    Official Full Name
    Pex9p
    Primary source
    SGD:S000004620
    Locus tag
    YMR018W
    See related
    AllianceGenome:SGD:S000004620; FungiDB:YMR018W; VEuPathDB:YMR018W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable peroxisome matrix targeting signal-1 binding activity. Involved in protein import into peroxisome matrix. Located in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to human PEX5 (peroxisomal biogenesis factor 5) and PEX5L (peroxisomal biogenesis factor 5 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PEX9 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (310208..311752)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Sok2p Neighboring gene Spo20p Neighboring gene Stb4p Neighboring gene polyamine oxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The budding yeast Pex5p receptor directs Fox2p and Cta1p into peroxisomes via its N-terminal region near the FxxxW domain. Rymer Ł, et al. J Cell Sci, 2018 Sep 7. PMID 30131444
    2. Determining the targeting specificity of the selective peroxisomal targeting factor Pex9. Yifrach E, et al. Biol Chem, 2023 Feb 23. PMID 36279206
    3. Membrane Processing and Steady-State Regulation of the Alternative Peroxisomal Import Receptor Pex9p. Rudowitz M, et al. Front Cell Dev Biol, 2020. PMID 33195197, Free PMC Article
    4. Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals. Amery L, et al. Biochem J, 2001 Aug 1. PMID 11463335, Free PMC Article
    5. Ammonia pulses and metabolic oscillations guide yeast colony development. Palková Z, et al. Mol Biol Cell, 2002 Nov. PMID 12429834, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables peroxisome matrix targeting signal-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxisome matrix targeting signal-1 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into peroxisome matrix IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pex9p
    NP_013731.1
    • Peroxisomal membrane signal receptor for peroxisomal matrix proteins; oleate-inducible condition-specific import receptor for a subset of PTS1-containing matrix proteins; localizes to both the cytosol and the peroxisomal membrane; similar to human PEX5Rp, a peroxin protein 5 related protein; paralog of Pex5p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      310208..311752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182514.1 → NP_013731.1  TPA: Pex9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013731.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZJ2, Q04364, Q6B2L0
      UniProtKB/TrEMBL
      B3LLS0, B5VPE5, C7GLA1, C8ZEM6, G2WK69, N1NY68
      Conserved Domains (2) summary
      TIGR02917
      Location:234 → 455
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:360 → 388
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04364.1

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