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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854080, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000005435
    Locus tag
    YOL075C
    See related
    AllianceGenome:SGD:S000005435; FungiDB:YOL075C; VEuPathDB:YOL075C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; obesity; and sitosterolemia 1. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (189658..193542, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ribosome biogenesis protein BRX1 Neighboring gene Mdm20p Neighboring gene Dsc2p Neighboring gene Thp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Engineering endogenous ABC transporter with improving ATP supply and membrane flexibility enhances the secretion of β-carotene in Saccharomyces cerevisiae. Bu X, et al. Biotechnol Biofuels, 2020. PMID 33062054, Free PMC Article
    2. The yeast ATP-binding cassette (ABC) transporter Ycf1p enhances the recruitment of the soluble SNARE Vam7p to vacuoles for efficient membrane fusion. Sasser TL, et al. J Biol Chem, 2013 Jun 21. PMID 23658021, Free PMC Article
    3. ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae. Rockwell NC, et al. J Membr Biol, 2009 May. PMID 19452121, Free PMC Article
    4. Development of a multiplexed microfluidic proteomic reactor and its application for studying protein-protein interactions. Tian R, et al. Anal Chem, 2011 Jun 1. PMID 21520965
    5. Control of Plasma Membrane Permeability by ABC Transporters. Khakhina S, et al. Eukaryot Cell, 2015 May. PMID 25724885, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_014567.2
    • Putative ABC transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      189658..193542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183329.2 → NP_014567.2  TPA: uncharacterized protein YOL075C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014567.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1Z3, Q08233, Q08234
      UniProtKB/TrEMBL
      A6ZND6, B3LIY6, C8ZHP2, G2WMG0, N1NX74
      Conserved Domains (1) summary
      TIGR00956
      Location:55 → 1236
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08234.3

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