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    ISM1 isoleucine--tRNA ligase ISM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856067, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ISM1
    Official Full Name
    isoleucine--tRNA ligase ISM1
    Primary source
    SGD:S000005961
    Locus tag
    YPL040C
    See related
    AllianceGenome:SGD:S000005961; FungiDB:YPL040C; VEuPathDB:YPL040C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable isoleucine-tRNA ligase activity. Involved in mitochondrial translation. Located in mitochondrion. Used to study mitochondrial metabolism disease. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ISM1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (475993..479001, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene cyclin-dependent serine/threonine protein kinase SSN3 Neighboring gene Mrx11p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes. Tzagoloff A, et al. Eur J Biochem, 1995 Jun 1. PMID 7607232
    2. Leucyl-tRNA synthetase-dependent and -independent activation of a group I intron. Boniecki MT, et al. J Biol Chem, 2009 Sep 25. PMID 19622748, Free PMC Article
    3. The mitochondrial cytochrome c peroxidase Ccp1 of Saccharomyces cerevisiae is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7). Charizanis C, et al. Mol Gen Genet, 1999 Oct. PMID 10589830
    4. Structural and functional role of bases 32 and 33 in the anticodon loop of yeast mitochondrial tRNAIle. Montanari A, et al. RNA, 2011 Nov. PMID 21914842, Free PMC Article
    5. A viable amino acid editing activity in the leucyl-tRNA synthetase CP1-splicing domain is not required in the yeast mitochondria. Karkhanis VA, et al. J Biol Chem, 2006 Nov 3. PMID 16956879

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoleucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoleucine-tRNA ligase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isoleucine--tRNA ligase ISM1
    NP_015285.1
    • Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      475993..479001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183854.1 → NP_015285.1  TPA: isoleucine--tRNA ligase ISM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015285.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3X3, P48526
      UniProtKB/TrEMBL
      A6ZWK7, N1NVI2
      Conserved Domains (1) summary
      TIGR00392
      Location:35 → 920
      ileS; isoleucyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48526.2

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