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    LGE1 Lge1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856052, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LGE1
    Official Full Name
    Lge1p
    Primary source
    SGD:S000005976
    Locus tag
    YPL055C
    See related
    AllianceGenome:SGD:S000005976; FungiDB:YPL055C; VEuPathDB:YPL055C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables molecular condensate scaffold activity. Involved in premeiotic DNA replication. Is active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LGE1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (453992..454990, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mannosylinositol phosphorylceramide synthase catalytic subunit SUR1 Neighboring gene Lcl1p Neighboring gene Lee1p Neighboring gene putative mannosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phase separation directs ubiquitination of gene-body nucleosomes. Gallego LD, et al. Nature, 2020 Mar. PMID 32214243, Free PMC Article
    2. H2B ubiquitination: Conserved molecular mechanism, diverse physiologic functions of the E3 ligase during meiosis. Wang L, et al. Nucleus, 2017 Sep 3. PMID 28628358, Free PMC Article
    3. Anethole potentiates dodecanol's fungicidal activity by reducing PDR5 expression in budding yeast. Fujita KI, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27632201
    4. Bre1 mediates the ubiquitination of histone H2B by regulating Lge1 stability. Kim J, et al. FEBS Lett, 2018 May. PMID 29637554
    5. Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination. Zhang X, et al. J Biol Chem, 2005 Jan 28. PMID 15528187

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bre1 mediates the ubiquitination of histone H2B by regulating Lge1 stability
      Title: Bre1 mediates the ubiquitination of histone H2B by regulating Lge1 stability.
    2. Lge1 has a novel function in disrupting the balance between the recruitment of Bre1 and Ubp8, thus promoting transcription elongation
      Title: A Bre1-associated protein, large 1 (Lge1), promotes H2B ubiquitylation during the early stages of transcription elongation.
    3. Lge1p has roles in gene regulation independent of its participation in the Rad6p-dependent ubiquitination of H2B
      Title: Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular condensate scaffold activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in premeiotic DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size HMP PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lge1p
    NP_015270.1
    • Protein that facilitates co-transcriptional histone H2B ubiquitination; scaffold protein that promotes oligomerization of E3 ligase Bre1p; contains an intrinsically disordered region that phase separates, to form a core encapsulated by Bre1p that recruits Ub-conjugating enzyme Rad6p, elevating catalytic activity along gene bodies; null mutant forms abnormally large cells, and homozygous null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      453992..454990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183869.1 → NP_015270.1  TPA: Lge1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3V9, Q02796, Q6Q5I8
      UniProtKB/TrEMBL
      G2WPC3, N1NX97
      Conserved Domains (1) summary
      pfam11488
      Location:251 → 329
      Lge1; Transcriptional regulatory protein LGE1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02796.1

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