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    aldo-keto reductase superfamily protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856017, updated on 9-Dec-2024

    Summary

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    Official Full Name
    aldo-keto reductase superfamily protein
    Primary source
    SGD:S000006009
    Locus tag
    YPL088W
    See related
    AllianceGenome:SGD:S000006009; FungiDB:YPL088W; VEuPathDB:YPL088W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable aryl-alcohol dehydrogenase (NADP+) activity. Predicted to be involved in cellular aldehyde metabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to several human genes including KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1) and KCNAB3 (potassium voltage-gated channel subfamily A regulatory beta subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (381965..382993)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S6A Neighboring gene Rlm1p Neighboring gene alkaline dihydroceramidase Neighboring gene Elongator subunit ELP3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Predicting subcellular localization of proteins using protein-protein interaction data. Garapati HS, et al. Genomics, 2020 May. PMID 31945465
    2. Disruption of seven hypothetical aryl alcohol dehydrogenase genes from Saccharomyces cerevisiae and construction of a multiple knock-out strain. Delneri D, et al. Yeast, 1999 Nov. PMID 10572264
    3. Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. Lucau-Danila A, et al. J Biol Chem, 2003 Dec 26. PMID 14512416
    4. Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis. Wild P, et al. Mol Cell, 2019 Aug 22. PMID 31351878, Free PMC Article
    5. Annotating novel genes by integrating synthetic lethals and genomic information. Schöner D, et al. BMC Syst Biol, 2008 Jan 14. PMID 18194531, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aryl-alcohol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aldehyde metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldo-keto reductase superfamily protein
    NP_015237.1
    • Putative aryl alcohol dehydrogenase; localizes to cytosol; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      381965..382993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183902.1 → NP_015237.1  TPA: aldo-keto reductase superfamily protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3S9, Q02895
      UniProtKB/TrEMBL
      G2WP93, N1NVH2
      Conserved Domains (1) summary
      cd19079
      Location:5 → 332
      AKR_EcYajO-like; Escherichia coli YajO and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02895.1

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