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    GND2 phosphogluconate dehydrogenase (decarboxylating) GND2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GND2
    Official Full Name
    phosphogluconate dehydrogenase (decarboxylating) GND2
    Primary source
    SGD:S000003488
    Locus tag
    YGR256W
    See related
    AllianceGenome:SGD:S000003488; FungiDB:YGR256W; VEuPathDB:YGR256W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphogluconate dehydrogenase (decarboxylating) activity. Involved in pentose-phosphate shunt, oxidative branch. Located in plasma membrane. Orthologous to human PGD (phosphogluconate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GND2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1004624..1006102)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative N,N-dimethylaniline monooxygenase COQ6 Neighboring gene tRNA-Thr Neighboring gene Mtm1p Neighboring gene ssDNA endodeoxyribonuclease RAD2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of specific enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone in Saccharomyces cerevisiae. Sinha A, et al. J Gen Microbiol, 1992 Sep. PMID 1328471
    2. Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional (13)C labeling of common amino acids. Maaheimo H, et al. Eur J Biochem, 2001 Apr. PMID 11298766
    3. Disorders in NADPH generation via pentose phosphate pathway influence the reproductive potential of the Saccharomyces cerevisiae yeast due to changes in redox status. Kwolek-Mirek M, et al. J Cell Biochem, 2019 May. PMID 30474881
    4. Comparative studies on the glycolytic and hexose monophosphate pathways in Candida parapsilosis and Saccharomyces cerevisiae. Caubet R, et al. Arch Microbiol, 1988. PMID 2833196
    5. Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated. Castelli LM, et al. Mol Biol Cell, 2011 Sep. PMID 21795399, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphogluconate dehydrogenase (decarboxylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphogluconate dehydrogenase (decarboxylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphogluconate dehydrogenase (decarboxylating) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-gluconate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in D-gluconate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    phosphogluconate dehydrogenase (decarboxylating) GND2
    NP_011772.3
    • 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1004624..1006102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181385.3 → NP_011772.3  TPA: phosphogluconate dehydrogenase (decarboxylating) GND2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011772.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV36, P53319
      UniProtKB/TrEMBL
      A6ZUR4, G2WEY2, N1P4G1
      Conserved Domains (1) summary
      TIGR00873
      Location:7 → 480
      gnd; 6-phosphogluconate dehydrogenase (decarboxylating)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53319.1

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