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    RPL6B ribosomal 60S subunit protein L6B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL6B
    Official Full Name
    ribosomal 60S subunit protein L6B
    Primary source
    SGD:S000004440
    Locus tag
    YLR448W
    See related
    AllianceGenome:SGD:S000004440; FungiDB:YLR448W; VEuPathDB:YLR448W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. A structural constituent of ribosome. Involved in cytoplasmic translation and ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL6B in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    2
    Sequence:
    Chromosome: XII; NC_001144.5 (1028854..1029768)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene hexokinase Neighboring gene H(+)-transporting V0 sector ATPase subunit d Neighboring gene peptidylprolyl isomerase FPR4 Neighboring gene hydroxymethylglutaryl-CoA reductase (NADPH) HMG2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast ribosomal proteins: XIV. Complete nucleotide sequences of the two genes encoding Saccharomyces cerevisiae YL16. Hashimoto T, et al. Biochim Biophys Acta, 1992 Sep 24. PMID 1390890
    2. GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae. Foiani M, et al. Mol Cell Biol, 1991 Jun. PMID 2038326, Free PMC Article
    3. Depletion of Saccharomyces cerevisiae ribosomal protein L16 causes a decrease in 60S ribosomal subunits and formation of half-mer polyribosomes. Rotenberg MO, et al. Genes Dev, 1988 Feb. PMID 3282992
    4. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. Kwan EX, et al. PLoS Genet, 2013. PMID 23505383, Free PMC Article
    5. Decreasing cytosolic translation is beneficial to yeast and human Tafazzin-deficient cells. de Taffin de Tilques M, et al. Microb Cell, 2018 Feb 18. PMID 29796387, Free PMC Article

    See all (137) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L6B
    NP_013553.1
    • Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1028854..1029768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182336.1 → NP_013553.1  TPA: ribosomal 60S subunit protein L6B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013553.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ82, P05739
      UniProtKB/TrEMBL
      A7A1W7, B3RHV6, C8ZE55, G2WJQ9, N1NYW5
      Conserved Domains (1) summary
      cd13156
      Location:26 → 176
      KOW_RPL6; KOW motif of Ribosomal Protein L6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05739.4

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