RPL3 ribosomal 60S subunit protein L3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPL3
Official Full Name: ribosomal 60S subunit protein L3
Primary source: SGD:S000005589
Locus tag: YOR063W
See related: AllianceGenome:SGD:S000005589; FungiDB:YOR063W; VEuPathDB:YOR063W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MAK8; TCM1; YOR29-14
Summary: Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Involved in gene expression and ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2D. Orthologous to human RPL3 (ribosomal protein L3) and RPL3L (ribosomal protein L3 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPL3 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (444686..445849)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rpl3 methylation at H243 is playing a significant role in translation elongation.
Title: Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity.
We conclude that L3 plays an important role in the function of eIF5B in stimulating 3' end processing of 18S rRNA in the context of 80S ribosomes that have not yet engaged in translation.
Title: Final pre-40S maturation depends on the functional integrity of the 60S subunit ribosomal protein L3.
3-methylhistidine modification of Rpl3 is dependent upon the YIL110W methyltransferase.
Title: A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase.
Upon depletion of Rpl3p, early assembly of 60S ribosomal subunits is aborted and subsequent steps during their maturation and export prevented.
Title: Functional analysis of Saccharomyces cerevisiae ribosomal protein Rpl3p in ribosome synthesis.
A mutant gene responsible for curvularol resistance was identified as an allele of the RPL3 gene encoding the ribosomal protein L3.
Title: Identification of Saccharomyces cerevisiae ribosomal protein L3 as a target of curvularol, a G1-specific inhibitor of mammalian cells.
To understand how ribosomal proteins may influence ribosome function, the large-scale mutational analysis of ribosomal protein L3 was performed.
Title: Identification of functionally important amino acids of ribosomal protein L3 by saturation mutagenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IC Inferred by Curator more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in maintenance of translational fidelity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal 60S subunit protein L3

NP_014706.1

Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in context of 80S ribosomes that have not yet engaged in translation; involved in replication and maintenance of killer double stranded RNA virus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

444686..445849

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183482.1 → NP_014706.1 TPA: ribosomal 60S subunit protein L3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014706.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2C6, P14126, Q08459

UniProtKB/TrEMBL

A6ZNR5, B3LJB2, C7GX55, C8ZI24, G2WMU1, N1NWW2

Conserved Domains (1) summary

PTZ00103
Location:1 → 387

PTZ00103; 60S ribosomal protein L3; Provisional