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    HDA3 Hda3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856309, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HDA3
    Official Full Name
    Hda3p
    Primary source
    SGD:S000006383
    Locus tag
    YPR179C
    See related
    AllianceGenome:SGD:S000006383; FungiDB:YPR179C; VEuPathDB:YPR179C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PLO1
    Summary
    Enables DNA binding activity and chromatin binding activity. Contributes to histone deacetylase activity. Involved in chromosome segregation; negative regulation of transcription by RNA polymerase II; and regulatory ncRNA-mediated gene silencing. Located in cytosol and nucleus. Part of HDA1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HDA3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (893797..895764, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rab geranylgeranyltransferase BET2 Neighboring gene U4/U6-U5 snRNP complex subunit PRP4 Neighboring gene E1 ubiquitin-activating protein AOS1 Neighboring gene GTPase-activating protein SEC23

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex. Carmen AA, et al. J Biol Chem, 1996 Jun 28. PMID 8663039
    2. Structural and functional studies of the yeast class II Hda1 histone deacetylase complex. Lee JH, et al. J Mol Biol, 2009 Aug 28. PMID 19573535
    3. Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Lee JH, et al. Sci Adv, 2021 Jan. PMID 33523989, Free PMC Article
    4. A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers. Zhou L, et al. G3 (Bethesda), 2021 Dec 8. PMID 34550356, Free PMC Article
    5. HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Wu J, et al. Proc Natl Acad Sci U S A, 2001 Apr 10. PMID 11287668, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleosome array spacer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HDA1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HDA1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of HDA1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hda3p
    NP_015505.1
    • Subunit of HDA1 histone deacetylase complex; tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for activity of complex; relocalizes to cytosol in response to hypoxia; similar to Hda2p; the HDA1 histone deacetylase complex regulates aging through trehalose metabolism

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      893797..895764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184276.1 → NP_015505.1  TPA: Hda3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015505.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4H9, Q06623
      UniProtKB/TrEMBL
      C7GP61
      Conserved Domains (2) summary
      COG1196
      Location:459 → 623
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11496
      Location:26 → 299
      HDA2-3; Class II histone deacetylase complex subunits 2 and 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06623.1

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