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    MIG2 Mig2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852663, updated on 27-Dec-2024

    Summary

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    Official Symbol
    MIG2
    Official Full Name
    Mig2p
    Primary source
    SGD:S000003177
    Locus tag
    YGL209W
    See related
    AllianceGenome:SGD:S000003177; FungiDB:YGL209W; VEuPathDB:YGL209W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MLZ1
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of filamentous growth of a population of unicellular organisms in response to starvation; and positive regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Orthologous to human ZNF148 (zinc finger protein 148) and ZNF281 (zinc finger protein 281). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MIG2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (95858..97006)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Ncs6p Neighboring gene Rab family GTPase YPT32 Neighboring gene Sip2p Neighboring gene chromatin-remodeling protein SPT16

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Investigation of the impact of MIG1 and MIG2 on the physiology of Saccharomyces cerevisiae. Klein CJ, et al. J Biotechnol, 1999 Feb 19. PMID 10194857
    2. RNase III-mediated silencing of a glucose-dependent repressor in yeast. Ge D, et al. Curr Biol, 2005 Jan 26. PMID 15668170
    3. Isolation and characterization of the LGT1 gene encoding a low-affinity glucose transporter from Torulaspora delbrueckii. Alves-Araújo C, et al. Yeast, 2005 Feb. PMID 15704215
    4. Engineering of carbon catabolite repression in recombinant xylose fermenting Saccharomyces cerevisiae. Roca C, et al. Appl Microbiol Biotechnol, 2004 Feb. PMID 12925863
    5. Environment-specific combinatorial cis-regulation in synthetic promoters. Gertz J, et al. Mol Syst Biol, 2009. PMID 19225457, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Mig2 nuclear import mechanism bypasses the requirement for Kap60 (importin-alpha) as an adaptor protein.
      Title: Yeast importin-β is required for nuclear import of the Mig2 repressor.
    2. The acetate production for the mig1/mig2 double mutant was reduced by 69.72% compared to the parent strain.
      Title: The impact of MIG1 and/or MIG2 disruption on aerobic metabolism of succinate dehydrogenase negative Saccharomyces cerevisiae.
    3. Mig2 repress a largely overlapping set of genes on 2% glucose.Mig2 fine-tunes glucose repression by targeting a subset of the Mig1-repressed genes
      Title: Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbon catabolite repression of transcription from RNA polymerase II promoter by glucose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mig2p
    NP_011306.1
    • Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced gene repression; under low glucose conditions relocalizes to mitochondrion, where it interacts with Ups1p, antagonizes mitochondrial fission factor Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth in response to glucose depletion; activated in stochastic pulses of nuclear localization in response to low glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      95858..97006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181074.1 → NP_011306.1  TPA: Mig2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011306.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTU6, O11853, O11854, P53035
      UniProtKB/TrEMBL
      A6ZTY0, B3LHQ5, B5VIC4, C7GWY7, N1P4I9
      Conserved Domains (2) summary
      COG5048
      Location:1 → 381
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:19 → 39
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53035.1

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