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    ISD11 Isd11p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ISD11
    Official Full Name
    Isd11p
    Primary source
    SGD:S000007237
    Locus tag
    YER048W-A
    See related
    AllianceGenome:SGD:S000007237; FungiDB:YER048W-A; VEuPathDB:YER048W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to cysteine desulfurase activity. Involved in iron-sulfur cluster assembly. Located in mitochondrial matrix. Part of L-cysteine desulfurase complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 19. Orthologous to human LYRM4 (LYR motif containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ISD11 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (250718..251002)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Caj1p Neighboring gene tRNA-Gln Neighboring gene oxidative DNA demethylase Neighboring gene mitochondrial 37S ribosomal protein RSM18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the Isd11-IscS complex reveals a single alpha-proteobacterial endosymbiosis for all eukaryotes. Richards TA, et al. Mol Biol Evol, 2006 Jul. PMID 16648156
    2. Identification of a Nfs1p-bound persulfide intermediate in Fe-S cluster synthesis by intact mitochondria. Pandey A, et al. Mitochondrion, 2012 Sep. PMID 22813754, Free PMC Article
    3. Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. Wiedemann N, et al. EMBO J, 2006 Jan 11. PMID 16341089, Free PMC Article
    4. Persulfide formation on mitochondrial cysteine desulfurase: enzyme activation by a eukaryote-specific interacting protein and Fe-S cluster synthesis. Pandey A, et al. Biochem J, 2012 Dec 1. PMID 22928949
    5. Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes. Lim SC, et al. Hum Mol Genet, 2013 Nov 15. PMID 23814038, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results show that Nfs1 adopts a higher oligomeric state in the Isd11-bound form compared to that in the free form
      Title: The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1.
    2. Whereas Nfs1p by itself was inactive, the Nfs1p.Isd11p complex formed persulfide and was active as a cysteine desulfurase. In the absence of Isd11p, Nfs1p was able to bind the substrate cysteine but failed to form a persulfide.
      Title: Persulfide formation on mitochondrial cysteine desulfurase: enzyme activation by a eukaryote-specific interacting protein and Fe-S cluster synthesis.
    3. Isd11 acts together with Nfs1 in an early step in the biogenesis of Fe/S proteins.
      Title: The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria.
    4. Isd11 is an indispensable eukaryotic component of the mitochondrial machinery for biogenesis of Fe/S proteins.
      Title: Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cysteine desulfurase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of L-cysteine desulfurase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of L-cysteine desulfurase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Isd11p
    NP_010968.1
    • Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      250718..251002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184330.1 → NP_010968.1  TPA: Isd11p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010968.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLV0, Q6Q560
      UniProtKB/TrEMBL
      A6ZQZ9, B3LS62, C7GSJ7, C8Z752, G2WCT3, N1P3D0
      Conserved Domains (1) summary
      cd20264
      Location:11 → 79
      Complex1_LYR_LYRM4; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q560.1

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