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    PIP2 oleate-activated transcription factor PIP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854545, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PIP2
    Official Full Name
    oleate-activated transcription factor PIP2
    Primary source
    SGD:S000005890
    Locus tag
    YOR363C
    See related
    AllianceGenome:SGD:S000005890; FungiDB:YOR363C; VEuPathDB:YOR363C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OAF2
    Summary
    Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to oleic acid; positive regulation of fatty acid beta-oxidation; and positive regulation of transcription by RNA polymerase II. Part of Pip2-Oaf1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PIP2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1020222..1023212, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF3 core subunit b Neighboring gene proteasome core particle subunit alpha 7 Neighboring gene putative flavin adenine dinucleotide transporter Neighboring gene Scp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Correlative AFM and fluorescence imaging demonstrate nanoscale membrane remodeling and ring-like and tubular structure formation by septins. Vial A , et al. Nanoscale, 2021 Aug 7. PMID 34225356
    2. Pip2p: a transcriptional regulator of peroxisome proliferation in the yeast Saccharomyces cerevisiae. Rottensteiner H, et al. EMBO J, 1996 Jun 17. PMID 8670793, Free PMC Article
    3. Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae. Gurvitz A, et al. Biochim Biophys Acta, 2001 Sep 28. PMID 11566445
    4. Saccharomyces cerevisiae Pip2p-Oaf1p regulates PEX25 transcription through an adenine-less ORE. Rottensteiner H, et al. Eur J Biochem, 2003 May. PMID 12709061
    5. Functional analysis of the Zn(2)Cys(6) transcription factors Oaf1p and Pip2p. Different roles in fatty acid induction of beta-oxidation in Saccharomyces cerevisiae. Baumgartner U, et al. J Biol Chem, 1999 Aug 6. PMID 10428786

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We thus uncover a meiotic functional role for TAO3, and identify ERT1 and PIP2 as novel regulators of sporulation efficiency. Our results demonstrate that studying the causal effects of genetic variation on the underlying molecular network has the potential to provide a more extensive understanding of the pathways driving a complex trait
      Title: Meiotic Interactors of a Mitotic Gene TAO3 Revealed by Functional Analysis of its Rare Variant.
    2. Data indicate that Oaf1p, Pip2p and Adr1p are required for the initial binding of Oaf3p before oleate induction.
      Title: Role of the repressor Oaf3p in the recruitment of transcription factors and chromatin dynamics during the oleate response.
    3. In the absence of Pip2, Oaf1 may form homodimers.
      Title: Yeast transcription factor Oaf1 forms homodimer and induces some oleate-responsive genes in absence of Pip2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oleic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Pip2-Oaf1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Pip2-Oaf1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oleate-activated transcription factor PIP2
    NP_015008.3
    • Autoregulatory, oleate-activated transcription factor; subunit of a heterodimeric complex with Oaf1p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; PIP2 has a paralog, OAF1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1020222..1023212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183783.3 → NP_015008.3  TPA: oleate-activated transcription factor PIP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015008.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W358, P52960
      UniProtKB/TrEMBL
      A6ZPJ3, B3LK20, N1NZ08
      Conserved Domains (2) summary
      cd12148
      Location:274 → 676
      fungal_TF_MHR; fungal transcription factor regulatory middle homology region
      cd00067
      Location:20 → 55
      GAL4; GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52960.1

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