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    LSC1 succinate--CoA ligase (GDP-forming) subunit alpha [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854310, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LSC1
    Official Full Name
    succinate--CoA ligase (GDP-forming) subunit alpha
    Primary source
    SGD:S000005668
    Locus tag
    YOR142W
    See related
    AllianceGenome:SGD:S000005668; FungiDB:YOR142W; VEuPathDB:YOR142W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to succinate-CoA ligase (ADP-forming) activity. Involved in succinyl-CoA metabolic process. Located in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LSC1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (593057..594046)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Sfl1p Neighboring gene Arp8p Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genes of succinyl-CoA ligase from Saccharomyces cerevisiae. Przybyla-Zawislak B, et al. Eur J Biochem, 1998 Dec 1. PMID 9874242
    2. Conservation of Transit Peptide-Independent Protein Import into the Mitochondrial and Hydrogenosomal Matrix. Garg S, et al. Genome Biol Evol, 2015 Sep 2. PMID 26338186, Free PMC Article
    3. Engineering an NADPH/NADP(+) Redox Biosensor in Yeast. Zhang J, et al. ACS Synth Biol, 2016 Dec 16. PMID 27419466
    4. Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions. Taylor MB, et al. PLoS Genet, 2015 Oct. PMID 26484664, Free PMC Article
    5. Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Przybyla-Zawislak B, et al. Genetics, 1999 May. PMID 10224250, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to succinate-CoA ligase (ADP-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate-CoA ligase (ADP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to succinate-CoA ligase (ADP-forming) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables succinate-CoA ligase (GDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in succinyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of succinate-CoA ligase complex (ADP-forming) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    succinate--CoA ligase (GDP-forming) subunit alpha
    NP_014785.3
    • Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      593057..594046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183561.3 → NP_014785.3  TPA: succinate--CoA ligase (GDP-forming) subunit alpha [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014785.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2J8, P53598
      UniProtKB/TrEMBL
      A6ZNY7, B3LJI0, B5VS30, C7GN81, C8ZIA4, G2WN15, N1NX04
      Conserved Domains (1) summary
      PTZ00187
      Location:24 → 327
      PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53598.1

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