SEC59 dolichol kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEC59
Official Full Name: dolichol kinase
Primary source: SGD:S000004615
Locus tag: YMR013C
See related: AllianceGenome:SGD:S000004615; FungiDB:YMR013C; VEuPathDB:YMR013C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables dolichol kinase activity. Involved in dolichyl monophosphate biosynthetic process. Located in endoplasmic reticulum membrane. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Im. Orthologous to human DOLK (dolichol kinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SEC59 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (295179..296738, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crosstalk between protein N-glycosylation and lipid metabolism in Saccharomyces cerevisiae.
Title: Crosstalk between protein N-glycosylation and lipid metabolism in Saccharomyces cerevisiae.
Two temperature-sensitive Saccharomyces cerevisiae mutants, sec59-1 and dpm1-6, impaired, respectively, in dolichol kinase (Sec59p) and dolichyl phosphate mannose (DolPMan) synthase (Dpm1p), have an aberrant cell wall structure and composition.
Title: Defect in dolichol-dependent glycosylation increases sensitivity of Saccharomyces cerevisiae towards anti-fungal drugs.
Evidence is presented that temperature-sensitive Saccharomyces cerevisiae mutants, impaired in dolichol kinase (Sec59p) or dolichyl phosphate mannose synthase (Dpm1p) activity have an aberrant cell wall composition and ultrastructure.
Title: Dissecting the role of dolichol in cell wall assembly in the yeast mutants impaired in early glycosylation reactions.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dolichol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichol kinase activity	IEA Inferred from Electronic Annotation more info
enables dolichol kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables dolichol kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dolichyl monophosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichyl monophosphate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dolichyl monophosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dolichol kinase

NP_013726.1

EC 2.7.1.108

Dolichol kinase; catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

295179..296738 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182509.1 → NP_013726.1 TPA: dolichol kinase [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZI7, P20048

UniProtKB/TrEMBL

A6ZM74, B3LLR4, C8ZEL9, G2WK64, N1P055

Conserved Domains (1) summary

COG0170
Location:283 → 519

SEC59; Dolichol kinase [Posttranslational modification, protein turnover, chaperones]