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    COX20 Cox20p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX20
    Official Full Name
    Cox20p
    Primary source
    SGD:S000002639
    Locus tag
    YDR231C
    See related
    AllianceGenome:SGD:S000002639; FungiDB:YDR231C; VEuPathDB:YDR231C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in mitochondrial cytochrome c oxidase assembly and negative regulation of programmed cell death. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COX20 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (926293..926910, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pcf11p Neighboring gene Ivy1p Neighboring gene 5-aminolevulinate synthase Neighboring gene Rtn1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of Mitochondrial Cytochrome C Oxidase Chaperone Gene (COX20) Improves Tolerance to Weak Acid and Oxidative Stress during Yeast Fermentation. Kumar V, et al. PLoS One, 2015. PMID 26427054, Free PMC Article
    2. The genetic basis of variation in clean lineages of Saccharomyces cerevisiae in response to stresses encountered during bioethanol fermentations. Greetham D, et al. PLoS One, 2014. PMID 25116161, Free PMC Article
    3. A Role for COX20 in Tolerance to Oxidative Stress and Programmed Cell Death in Saccharomyces cerevisiae. Keerthiraju E, et al. Microorganisms, 2019 Nov 18. PMID 31752220, Free PMC Article
    4. Global Proteome Remodeling during ER Stress Involves Hac1-Driven Expression of Long Undecoded Transcript Isoforms. Van Dalfsen KM, et al. Dev Cell, 2018 Jul 16. PMID 30016623, Free PMC Article
    5. Identification of Cox20p, a novel protein involved in the maturation and assembly of cytochrome oxidase subunit 2. Hell K, et al. J Biol Chem, 2000 Feb 18. PMID 10671482

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of Mitochondrial Cytochrome C Oxidase Chaperone Gene (COX20) Improves Tolerance to Weak Acid and Oxidative Stress during Yeast Fermentation
      Title: Expression of Mitochondrial Cytochrome C Oxidase Chaperone Gene (COX20) Improves Tolerance to Weak Acid and Oxidative Stress during Yeast Fermentation.
    2. The Cox20 chaperone has important roles in leader peptide processing, C-tail export, and stabilization of Cox2.
      Title: Multiple roles of the Cox20 chaperone in assembly of Saccharomyces cerevisiae cytochrome c oxidase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of programmed cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cox20p
    NP_010517.1
    • Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      926293..926910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180539.1 → NP_010517.1  TPA: Cox20p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSL2, Q04935
      UniProtKB/TrEMBL
      G2WAX5, N1P6W6
      Conserved Domains (1) summary
      pfam12597
      Location:62 → 164
      DUF3767; Protein of unknown function (DUF3767)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04935.1

    Gene LinkOut

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