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    TOM6 Tom6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854210, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TOM6
    Official Full Name
    Tom6p
    Primary source
    SGD:S000005571
    Locus tag
    YOR045W
    See related
    AllianceGenome:SGD:S000005571; FungiDB:YOR045W; VEuPathDB:YOR045W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ISP6; MOM8B
    Summary
    Contributes to protein transmembrane transporter activity. Involved in mitochondrial outer membrane translocase complex assembly and protein import into mitochondrial matrix. Located in mitochondrion. Part of mitochondrial outer membrane translocase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TOM6 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (413852..414037)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Whi2p Neighboring gene Irc23p Neighboring gene ATP-dependent RNA helicase DBP5 Neighboring gene Std1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial receptor complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore. Kiebler M, et al. Cell, 1993 Aug 13. PMID 8348615
    2. Specific targeting of ISP6 to mitochondria is mediated by sequences other than its amino terminus. Cao W, et al. Biochem Biophys Res Commun, 1996 Jul 16. PMID 8702410
    3. Biogenesis of ISP6, a small carboxyl-terminal anchored protein of the receptor complex of the mitochondrial outer membrane. Cao W, et al. J Biol Chem, 1995 Mar 10. PMID 7890690
    4. Genetic and biochemical characterization of ISP6, a small mitochondrial outer membrane protein associated with the protein translocation complex. Kassenbrock CK, et al. EMBO J, 1993 Aug. PMID 8344244, Free PMC Article
    5. Multiple functions of tail-anchor domains of mitochondrial outer membrane proteins. Habib SJ, et al. FEBS Lett, 2003 Dec 18. PMID 14675765

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tom6 phosphorylation provides a direct means for regulating mitochondrial biogenesis and activity in a cell cycle-specific manner.
      Title: Mitochondria. Cell cycle-dependent regulation of mitochondrial preprotein translocase.
    2. Overexpression of SAM37 suppresses the growth phenotype of tom6Delta, and cells lacking both genes are not viable.
      Title: Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial outer membrane translocase complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into mitochondrial matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tom6p
    NP_014688.1
    • Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      413852..414037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183464.1 → NP_014688.1  TPA: Tom6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014688.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2B1, P33448
      UniProtKB/TrEMBL
      A6ZNQ0, B3LJ97, C7GLH3, C8ZI07, G2WMS6, N1NWH0
      Conserved Domains (1) summary
      pfam17112
      Location:17 → 61
      Tom6; Mitochondrial import receptor subunit Tom6, fungal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33448.1

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