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    Mup4 major urinary protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 17843, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mup4provided by MGI
    Official Full Name
    major urinary protein 4provided by MGI
    Primary source
    MGI:MGI:97236
    See related
    Ensembl:ENSMUSG00000041333 AllianceGenome:MGI:97236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mup1; Mup-4
    Summary
    Predicted to enable insulin receptor activity and pheromone binding activity. Predicted to be involved in several processes, including regulation of gene expression; regulation of glucose metabolic process; and regulation of lipid metabolic process. Located in extracellular space. Is expressed in dermis and tail. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 2.5) See more
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    Genomic context

    See Mup4 in Genome Data Viewer
    Location:
    4 B3; 4 32.82 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59956804..59960667, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59956804..59960667, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene sorting nexin family member 30 Neighboring gene STARR-seq mESC enhancer starr_10384 Neighboring gene sorting nexin 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:59891511-59891739 Neighboring gene solute carrier family 46, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E4632 Neighboring gene STARR-seq mESC enhancer starr_10391 Neighboring gene STARR-seq mESC enhancer starr_10392 Neighboring gene STARR-seq mESC enhancer starr_10394 Neighboring gene major urinary protein 6 Neighboring gene major urinary protein, pseudogene 1 Neighboring gene major urinary protein 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables insulin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pheromone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aerobic respiration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to lipid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in energy reserve metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heat generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in locomotor rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    major urinary protein 4
    Names
    MUP 4
    major urinary protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008648.2NP_032674.1  major urinary protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL831738
      Consensus CDS
      CCDS18228.1
      UniProtKB/Swiss-Prot
      P11590
      UniProtKB/TrEMBL
      A2ANT5
      Related
      ENSMUSP00000075356.3, ENSMUST00000075973.3
      Conserved Domains (1) summary
      pfam00061
      Location:32171
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      59956804..59960667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)