Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpina3kprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A, member 3Kprovided by MGI
Primary source: MGI:MGI:98377
See related: Ensembl:ENSMUSG00000058207 AllianceGenome:MGI:98377
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RP54; Spi2; MMCM2; Spi-2; MMSpi2; D12Rp54; contrapsin; 1300001I07Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Located in collagen-containing extracellular matrix. Is expressed in axial skeleton; liver; nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward liver adult (RPKM 1557.0) See more
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Genomic context

Location:: 12 E; 12 53.99 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (104304745..104311998)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (104338486..104345739)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SerpinA3K Deficiency Reduces Oxidative Stress in Acute Kidney Injury.
Title: SerpinA3K Deficiency Reduces Oxidative Stress in Acute Kidney Injury.
SERPINA3K is involved in the Clock gene-mediated male fertility by regulating acrosin activity and provide the first evidence that SERPINA3K could be regulated by Clock gene via retinoic acid-related orphan receptor response elements.
Title: The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K.
structural analysis of the murine orthologue of human antichymotrypsin
Title: The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to cytokine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine protease inhibitor A3K

Names: alpha-1 antiproteinase; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3K; serine (or cysteine) proteinase inhibitor, clade A, member 3K; serine protease inhibitor 2; serpin A3K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011458.2 → NP_035588.2 serine protease inhibitor A3K precursor

Status: PROVISIONAL

Source sequence(s)

AK149436

Consensus CDS

CCDS36537.1

UniProtKB/Swiss-Prot

P07759, Q62257, Q8VCH3, Q91W80, Q91X80

UniProtKB/TrEMBL

A0A0R4J0I1

Related

ENSMUSP00000042095.4, ENSMUST00000043058.5

Conserved Domains (1) summary

smart00093
Location:57 → 417

SERPIN; SERine Proteinase INhibitors