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    Ppp2r5d protein phosphatase 2, regulatory subunit B', delta [ Mus musculus (house mouse) ]

    Gene ID: 21770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp2r5dprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B', deltaprovided by MGI
    Primary source
    MGI:MGI:2388481
    See related
    Ensembl:ENSMUSG00000059409 AllianceGenome:MGI:2388481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tex271; B'delta; TEG-271
    Summary
    Enables protein phosphatase activator activity. Predicted to be involved in negative regulation of peptidyl-threonine phosphorylation and protein dephosphorylation. Predicted to act upstream of or within several processes, including positive regulation of neurotrophin TRK receptor signaling pathway; positive regulation of transcription by RNA polymerase II; and regulation of protein autophosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to human PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 36.1), CNS E11.5 (RPKM 34.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp2r5d in Genome Data Viewer
    Location:
    17 22.9 cM; 17 C
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46993917..47015952, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46682991..46705026, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36 Neighboring gene kelch domain containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr17:46817738-46818039 Neighboring gene male enhanced antigen 1 Neighboring gene STARR-positive B cell enhancer ABC_E7538 Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene glycine N-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Novel Mouse Model of Combined Hepatocellular-Cholangiocarcinoma Induced by Diethylnitrosamine and Loss of Ppp2r5d. Domènech Omella J, et al. Cancers (Basel), 2023 Aug 21. PMID 37627221, Free PMC Article
    2. Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo. Lambrecht C, et al. Oncogene, 2018 Jan 25. PMID 28967903
    3. Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A. Ahn JH, et al. PLoS One, 2011. PMID 22046270, Free PMC Article
    4. Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis. Ortega-Lázaro JC, et al. Cytogenet Genome Res, 2003. PMID 15051958
    5. Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. Kapfhamer D, et al. J Neurosci, 2010 Jun 30. PMID 20592205, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ppp2r5d knockout mice are predisposed to spontaneous tumor development, providing the first in vivo evidence that validates a single PP2A complex as a bona fide tumor suppressor.
      Title: Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo.
    2. MiR-9 regulates GR signaling and steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity.
      Title: MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity.
    3. activation of the B56delta-containing heterotrimeric form of PP2A is responsible for enhanced dephosphorylation of Ser40 of tyrosine hydroylase in response to stimulation of PKC
      Title: Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A.
    4. Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.
      Title: Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.
    5. A comparative expression study of Ppp2r5d and Mea1 in spermatogenesis.
      Title: Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in meiotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
    Names
    testis expressed gene 271

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357684.1 → NP_001344613.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 2

      Status: VALIDATED

      Source sequence(s)
      BE948258, CT030702
      Consensus CDS
      CCDS89107.1
      UniProtKB/TrEMBL
      Q7TNL5, Q99PC9
      Related
      ENSMUSP00000156500.2, ENSMUST00000233988.2
      Conserved Domains (2) summary
      pfam01603
      Location:101 → 506
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
      cl27532
      Location:49 → 115
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. NM_009358.3 → NP_033384.2  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 1

      See identical proteins and their annotated locations for NP_033384.2

      Status: VALIDATED

      Source sequence(s)
      AK160587, CJ042073, CT030702
      Consensus CDS
      CCDS28836.1
      UniProtKB/TrEMBL
      Q91V89, Q99PC9
      Related
      ENSMUSP00000002839.9, ENSMUST00000002839.9
      Conserved Domains (2) summary
      pfam01603
      Location:100 → 505
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
      cl27532
      Location:48 → 114
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46993917..47015952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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