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    Mpzl2 myelin protein zero-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 14012, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mpzl2provided by MGI
    Official Full Name
    myelin protein zero-like 2provided by MGI
    Primary source
    MGI:MGI:1289160
    See related
    Ensembl:ENSMUSG00000032092 AllianceGenome:MGI:1289160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eva; Eva1
    Summary
    Acts upstream of or within T cell differentiation in thymus and cell-cell adhesion. Located in plasma membrane. Is expressed in several structures, including branchial arch; epithelium; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 111. Orthologous to human MPZL2 (myelin protein zero like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 17.0), placenta adult (RPKM 12.4) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mpzl2 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44951595..44965341)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45042344..45054043)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794321-44794504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794585-44794829 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44804746-44804978 Neighboring gene CD3 antigen, delta polypeptide Neighboring gene CD3 antigen, epsilon polypeptide Neighboring gene STARR-seq mESC enhancer starr_23989 Neighboring gene STARR-positive B cell enhancer mm9_chr9:44849180-44849480 Neighboring gene STARR-seq mESC enhancer starr_23990 Neighboring gene myelin protein zero-like 3 Neighboring gene junction adhesion molecule like Neighboring gene predicted gene 10684

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of expansion of CD11c(+) B cells and anti-viral immunity by epithelial V-like antigen. Dungan M, et al. Immunobiology, 2020 Mar. PMID 31818507
    2. MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse. Wesdorp M, et al. Am J Hum Genet, 2018 Jul 5. PMID 29961571, Free PMC Article
    3. A monoclonal antibody against the extracellular domain of mouse and human epithelial V-like antigen 1 reveals a restricted expression pattern among CD4- CD8- thymocytes. Garabatos N, et al. Monoclon Antib Immunodiagn Immunother, 2014 Oct. PMID 25357997, Free PMC Article
    4. Epithelial V-like antigen mediates efficacy of anti-alpha₄ integrin treatment in a mouse model of multiple sclerosis. Wright E, et al. PLoS One, 2013. PMID 23951051, Free PMC Article
    5. Epithelial V-like antigen regulates permeability of the blood-CSF barrier. Chatterjee G, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18498762, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We show that Mpzl2 is expressed in mouse inner ear, and the protein localizes in the auditory inner and outer hair cells, with an asymmetric subcellular localization. We thus present MPZL2 as a novel gene associated with sensorineural hearing loss.
      Title: MPZL2 is a novel gene associated with autosomal recessive nonsyndromic moderate hearing loss.
    2. EVA deficiency results in increased experimental autoimmune encephalomyelitis disease severity. EVA-knockout Mice have normal immune system development and choroid plexus morphology.
      Title: Epithelial V-like antigen mediates efficacy of anti-alpha₄ integrin treatment in a mouse model of multiple sclerosis.
    3. modulation of Eva1 expression in thymocytes is crucial for lymphocyte physiological developmental progression and stromal differentiation
      Title: Lymphoid EVA1 expression is required for DN1-DN3 thymocytes transition.
    4. These results suggest that EVA expressed in choroid plexus cells may regulate the permeability of the blood-CSF barrier.
      Title: Epithelial V-like antigen regulates permeability of the blood-CSF barrier.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myelin protein zero-like protein 2
    Names
    epithelial V-like antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357727.1 → NP_001344656.1  myelin protein zero-like protein 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC122305
      Consensus CDS
      CCDS23126.1
      UniProtKB/Swiss-Prot
      O70255
      UniProtKB/TrEMBL
      F6RG10, Q3TLS6
      Conserved Domains (1) summary
      cd05880
      Location:28 → 142
      Ig_EVA1; Immunoglobulin (Ig)-like domain of epithelial V-like antigen 1 (EVA)

    2. NM_007962.4 → NP_031988.2  myelin protein zero-like protein 2 precursor

      See identical proteins and their annotated locations for NP_031988.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK032788, AK167263, BY230064, BY387940
      Consensus CDS
      CCDS23126.1
      UniProtKB/Swiss-Prot
      O70255
      UniProtKB/TrEMBL
      F6RG10, Q3TLS6
      Related
      ENSMUSP00000034600.5, ENSMUST00000034600.5
      Conserved Domains (1) summary
      cd05880
      Location:28 → 142
      Ig_EVA1; Immunoglobulin (Ig)-like domain of epithelial V-like antigen 1 (EVA)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44951595..44965341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154609.1 → XP_036010502.1  myelin protein zero-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A1L1STN6
      Related
      ENSMUSP00000150395.2, ENSMUST00000217097.2
      Conserved Domains (2) summary
      cd00096
      Location:2 → 6
      Ig; Ig strand C" [structural motif]
      cl11960
      Location:2 → 62
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70255.1 GenPept UniProtKB/Swiss-Prot:O70255

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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