CCL23 C-C motif chemokine ligand 23 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCL23provided by HGNC
Official Full Name: C-C motif chemokine ligand 23provided by HGNC
Primary source: HGNC:HGNC:10622
See related: Ensembl:ENSG00000274736 MIM:602494; AllianceGenome:HGNC:10622
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; hmrp-2a; CK-BETA-8
Summary: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Expression: Broad expression in appendix (RPKM 3.6), lung (RPKM 2.2) and 15 other tissues See more
Orthologs: all
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Genomic context

Location:: 17q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (36013058..36017972, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (36960963..36965877, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (34340098..34345009, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Delayed CCL23 response is associated with poor outcomes after cardiac arrest.
Title: Delayed CCL23 response is associated with poor outcomes after cardiac arrest.
Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer.
Title: Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer.
Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma.
Title: Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma.
CCL23 suppresses liver cancer progression through the CCR1/AKT/ESR1 feedback loop.
Title: CCL23 suppresses liver cancer progression through the CCR1/AKT/ESR1 feedback loop.
CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease.
Title: CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease.
The low expression of CCL23 in hepatocellular carcinoma (HCC) tissue is not conducive to the development of anti-tumor immune defense in HCC patients and significantly shortens the survival of HCC patients.
Title: [Bioinformatics analysis and significance of expression of CC chemokine ligand 23 (CCL23) in hepatocellular carcinoma].
CCL23 is posttranslationally modified by trypsin-like serine proteases and CCL23(47-117) might be a major active form of CCL23 in nasal polyps with chronic rhinosinusitis.
Title: Tissue proteases convert CCL23 into potent monocyte chemoattractants in patients with chronic rhinosinusitis.
The coexistence of diabetes and oxidative stress independently affected CCL23 levels, while the presence of Cardiovascular disease and inflammation had no impact on its concentrations.
Title: Effect of diabetes and oxidative stress on plasma CCL23 levels in patients with severe chronic kidney disease.
ADAMTS 8, CCL23, and TNFSF15 are implicated in anti-angiogenic activities
Title: Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease.
Data show CCL23 stimulates chemotaxis of human THP-1 monocytes and enhances release of MMP-2, and suggest it plays a role in atherogenesis.
Title: Potential involvement of CCL23 in atherosclerotic lesion formation/progression by the enhancement of chemotaxis, adhesion molecule expression, and MMP-2 release from monocytes.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of lung function phenotypes in a founder population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr upregulates the gene expression of CCL23 in human monocyte-derived dendritic cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S2152 (e-PCR)
- UniSTS:51226

RH93904 (e-PCR)
- UniSTS:92055

NoName (e-PCR)
- UniSTS:483748

NoName (e-PCR)
- UniSTS:480703

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR1 chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in monocyte chemotaxis	IC Inferred by Curator more info	PubMed
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-C motif chemokine 23

Names: C6 beta-chemokine; chemokine (C-C motif) ligand 23; macrophage inflammatory protein 3; myeloid progenitor inhibitory factor 1; small inducible cytokine subfamily A (Cys-Cys), member 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029876.2 RefSeqGene

Range

4997..9911

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005064.6 → NP_005055.3 C-C motif chemokine 23 isoform CKbeta8-1 precursor

See identical proteins and their annotated locations for NP_005055.3

Status: REVIEWED

Description

Transcript Variant: This variant (CKbeta8-1) represents the longer transcript and encodes the longer isoform (CKbeta8-1).

Source sequence(s)

AC244100, BC143310, U58913, U85767

Consensus CDS

CCDS11305.1

UniProtKB/Swiss-Prot

P55773

Related

ENSP00000481357.1, ENST00000615050.2

Conserved Domains (1) summary

smart00199
Location:68 → 126

SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)
NM_145898.4 → NP_665905.2 C-C motif chemokine 23 isoform CKbeta8 precursor

See identical proteins and their annotated locations for NP_665905.2

Status: REVIEWED

Description

Transcript Variant: This variant (CKbeta8) uses an alternate, in-frame splice site in the coding region, compared to transcript variant CKbeta8-1. This difference results in a shorter protein (isoform CKbeta8) compared to isoform CKbeta8-1.

Source sequence(s)

AC244100, BC093970, U58913, U85767

Consensus CDS

CCDS59282.1

UniProtKB/Swiss-Prot

B7ZKQ3, O00174, O75950, P55773, Q52LD4

Related

ENSP00000484748.1, ENST00000612516.4

Conserved Domains (1) summary

smart00199
Location:51 → 109

SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)