Prss40 serine protease 40 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss40provided by MGI
Official Full Name: serine protease 40provided by MGI
Primary source: MGI:MGI:1270857
See related: Ensembl:ENSMUSG00000037529 AllianceGenome:MGI:1270857
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tesp2
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in acrosomal vesicle and extracellular region. Predicted to be active in extracellular space. Is expressed in bone marrow; brain; genitourinary system; and submandibular gland. Orthologous to human PRSS40A (serine protease 40A (pseudogene)) and PRSS40B (serine protease 40B (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 22.9) See more
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Genomic context

Location:: 1 B; 1 13.34 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (34575529..34600099, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (34536448..34561004, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491282

AV265756 (e-PCR)
- UniSTS:178369

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine protease 40

Names: protease, serine 40; testicular serine protease 2

NP_033382.2

EC 3.4.21.-

XP_006495919.1

EC 3.4.21.-

XP_006495920.1

EC 3.4.21.-

XP_006495921.1

EC 3.4.21.-

XP_006495922.1

EC 3.4.21.-

XP_006495923.1

EC 3.4.21.-

XP_006495924.1

EC 3.4.21.-

XP_006495925.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009356.2 → NP_033382.2 serine protease 40 precursor

See identical proteins and their annotated locations for NP_033382.2

Status: VALIDATED

Source sequence(s)

AC106841

Consensus CDS

CCDS14870.1

UniProtKB/Swiss-Prot

A6H6T1, E9QL09, O70170

Related

ENSMUSP00000045118.8, ENSMUST00000047840.9

Conserved Domains (2) summary

smart00020
Location:68 → 308

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:69 → 311

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

34575529..34600099 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495857.4 → XP_006495920.1 serine protease 40 isoform X2

Conserved Domains (1) summary

cd00190
Location:69 → 260

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006495862.4 → XP_006495925.1 serine protease 40 isoform X6

UniProtKB/TrEMBL

Q3V0T7

Conserved Domains (1) summary

cl21584
Location:2 → 141

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006495858.5 → XP_006495921.1 serine protease 40 isoform X3

Conserved Domains (1) summary

cd00190
Location:69 → 263

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006495856.5 → XP_006495919.1 serine protease 40 isoform X1

Conserved Domains (1) summary

cd00190
Location:69 → 260

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006495859.5 → XP_006495922.1 serine protease 40 isoform X4

Conserved Domains (1) summary

cd00190
Location:69 → 262

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006495861.2 → XP_006495924.1 serine protease 40 isoform X5

See identical proteins and their annotated locations for XP_006495924.1

Conserved Domains (1) summary

cd00190
Location:2 → 189

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006495860.2 → XP_006495923.1 serine protease 40 isoform X5

See identical proteins and their annotated locations for XP_006495923.1

Conserved Domains (1) summary

cd00190
Location:2 → 189

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...