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    stat3.2.L signal transducer and activator of transcription 3, gene 2 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 379264, updated on 4-Jan-2025

    Summary

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    Official Symbol
    stat3.2.L
    Official Full Name
    signal transducer and activator of transcription 3, gene 2 L homeolog
    Primary source
    Xenbase:XB-GENE-1020979
    Locus tag
    XELAEV_18043074mg
    See related
    EnsemblRapid:ENSXLAG00005036849 AllianceGenome:Xenbase:XB-GENE-1020979
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    aprf; hies; stat3-A; stat3.2
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity; protein homodimerization activity; and protein kinase binding activity. Predicted to act upstream of or within several processes, including interleukin-6-mediated signaling pathway; mesoderm formation; and neural crest cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in ectoderm; vestibuloauditory system; and visual system. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See stat3.2.L in Genome Data Viewer
    Location:
    chromosome: 9_10L
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (464054..489634)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (422836..446727)

    Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene caveolae associated protein 1 L homeolog Neighboring gene signal transducer and activator of transcription 3 gene 1 L homeolog Neighboring gene uncharacterized LOC121397899 Neighboring gene signal transducer and activator of transcription 5B L homeolog Neighboring gene GH3 domain containing L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC53512

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within interleukin-6-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within mesoderm formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neural crest cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 3.2
    Names
    signal transducer and activator of transcription 3 (acute-phase response factor), gene 2 L homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001086108.1 → NP_001079577.1  signal transducer and activator of transcription 3.2

      See identical proteins and their annotated locations for NP_001079577.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044717
      UniProtKB/Swiss-Prot
      Q7ZXK3
      UniProtKB/TrEMBL
      A0A974BWA6
      Conserved Domains (4) summary
      cd10374
      Location:554 → 715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2 → 119
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141 → 319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321 → 573
      STAT_bind; STAT protein, DNA binding domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      464054..489634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041575483.1 → XP_041431417.1  signal transducer and activator of transcription 3.2 isoform X1

      UniProtKB/TrEMBL
      A0A8J1LPE7, A0A974BWA6
      Related
      ENSXLAP00005110503.1, ENSXLAT00005112722.1
      Conserved Domains (4) summary
      cd10374
      Location:554 → 716
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2 → 119
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139 → 318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321 → 484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

    2. XM_041575482.1 → XP_041431416.1  signal transducer and activator of transcription 3.2 isoform X1

      UniProtKB/TrEMBL
      A0A8J1LPE7, A0A974BWA6
      Conserved Domains (4) summary
      cd10374
      Location:554 → 716
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2 → 119
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139 → 318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321 → 484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZXK3.1 GenPept UniProtKB/Swiss-Prot:Q7ZXK3

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials