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    Rnf149 ring finger protein 149 [ Mus musculus (house mouse) ]

    Gene ID: 67702, updated on 13-Jan-2025

    Summary

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    Official Symbol
    Rnf149provided by MGI
    Official Full Name
    ring finger protein 149provided by MGI
    Primary source
    MGI:MGI:2677438
    See related
    Ensembl:ENSMUSG00000048234 AllianceGenome:MGI:2677438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Greul4; Gm15832; 1600023E10Rik
    Summary
    Enables ubiquitin protein ligase activity. Acts upstream of or within cellular response to xenobiotic stimulus; negative regulation of MAPK cascade; and regulation of protein stability. Predicted to be located in membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and late endosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human RNF149 (ring finger protein 149). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in genital fat pad adult (RPKM 52.2), liver adult (RPKM 14.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf149 in Genome Data Viewer
    Location:
    1 B; 1 18.33 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (39590375..39616885, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (39551294..39577439, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 89 Neighboring gene predicted gene, 18446 Neighboring gene STARR-seq mESC enhancer starr_00724 Neighboring gene predicted gene, 23722 Neighboring gene predicted gene, 51620 Neighboring gene predicted gene 5100 Neighboring gene cellular repressor of E1A-stimulated genes 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF). Hong SW, et al. J Biol Chem, 2012 Jul 6. PMID 22628551, Free PMC Article
    2. Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice. Rouger K, et al. Am J Physiol Cell Physiol, 2002 Sep. PMID 12176734
    3. The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development. Borchers AG, et al. Dev Biol, 2002 Nov 15. PMID 12435366
    4. The role of RNF149 in the pre-emptive quality control substrate ubiquitination. Legesse A, et al. Commun Biol, 2023 Apr 8. PMID 37031316, Free PMC Article
    5. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of protein stability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF149
    Names
    RING-type E3 ubiquitin transferase RNF149
    goliath-related E3 ubiquitin-protein ligase 4
    NP_001028307.2
    XP_006496289.1
    XP_036009047.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033135.4 → NP_001028307.2  E3 ubiquitin-protein ligase RNF149 precursor

      Status: VALIDATED

      Source sequence(s)
      AC119809, AC122922
      Consensus CDS
      CCDS14907.1
      UniProtKB/Swiss-Prot
      E9QAH5, Q14BF0, Q3U2C5, Q8CGR2
      Related
      ENSMUSP00000050388.6, ENSMUST00000062525.11
      Conserved Domains (3) summary
      cd02122
      Location:45 → 181
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:263 → 306
      zf-RING_2; Ring finger domain
      cl11506
      Location:193 → 220
      UPF0233; uncharacterized protein family (UPF0233)

    RNA

    1. NR_197182.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC119809, AC122922

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      39590375..39616885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153154.1 → XP_036009047.1  E3 ubiquitin-protein ligase RNF149 isoform X1

      Conserved Domains (4) summary
      cd00162
      Location:108 → 148
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl28883
      Location:1 → 24
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
      cl11506
      Location:36 → 63
      CrgA; Cell division protein CrgA
      cl17238
      Location:107 → 154
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_006496226.5 → XP_006496289.1  E3 ubiquitin-protein ligase RNF149 isoform X1

      Conserved Domains (4) summary
      cd00162
      Location:108 → 148
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl28883
      Location:1 → 24
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
      cl11506
      Location:36 → 63
      CrgA; Cell division protein CrgA
      cl17238
      Location:107 → 154
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. XR_373259.5 RNA Sequence

    2. XR_004934117.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U2C5.3 GenPept UniProtKB/Swiss-Prot:Q3U2C5

    Gene LinkOut

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