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    STE3 Ste3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STE3
    Official Full Name
    Ste3p
    Primary source
    SGD:S000001661
    Locus tag
    YKL178C
    See related
    AllianceGenome:SGD:S000001661; FungiDB:YKL178C; VEuPathDB:YKL178C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DAF2
    Summary
    Enables mating-type a-factor pheromone receptor activity. Involved in cytogamy and pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STE3 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (113215..114627, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L17A Neighboring gene Coy1p Neighboring gene Lst4p Neighboring gene Zn(2+) transporter ZRT3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitination of the yeast a-factor receptor. Roth AF, et al. J Cell Biol, 1996 Aug. PMID 8707846, Free PMC Article
    2. Induction of the yeast alpha-specific STE3 gene by the peptide pheromone a-factor. Hagen DC, et al. J Mol Biol, 1984 Oct 5. PMID 6436496
    3. Mutations that alter the third cytoplasmic loop of the a-factor receptor lead to a constitutive and hypersensitive phenotype. Boone C, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 8234336, Free PMC Article
    4. A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans. Hsueh YP, et al. EMBO J, 2009 May 6. PMID 19322200, Free PMC Article
    5. Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor. Hagen DC, et al. Proc Natl Acad Sci U S A, 1986 Mar. PMID 3006051, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The main difference between the Ste2 and Ste3 receptor observed in this work was that while hyperactive mutations were found for Ste3, no gain-of-function mutant for the Ste2 receptor was found. this fi nding is an outcome of the different strategies the two genes have adopted for their expression.
      Title: Analysis of random PCR-originated mutants of the yeast Ste2 and Ste3 receptors.
    2. no cryptic poly(A) sites are present in the a-factor receptor STE3 gene, indicating that S. cerevisiae has devised different strategies to regulate the two receptor genes STE2 and STE3
      Title: Yeast pheromone receptor genes STE2 and STE3 are differently regulated at the transcription and polyadenylation level.
    3. an interaction between Ste2p and Ste3p has roles in yeast cellular mating
      Title: A role for a complex between activated G protein-coupled receptors in yeast cellular mating.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mating-type a-factor pheromone receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mating-type factor pheromone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mating-type factor pheromone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytogamy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytogamy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ste3p
    NP_012743.1
    • Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      113215..114627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179744.1 → NP_012743.1  TPA: Ste3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012743.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX23, P06783
      UniProtKB/TrEMBL
      A6ZZE8, B3LQS8, B5VLY6, C7GJ32, C8ZBZ7, G2WHL5, N1P0N0
      Conserved Domains (1) summary
      pfam02076
      Location:10 → 289
      STE3; Pheromone A receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06783.1

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